915095-96-4Relevant articles and documents
A SYNTHESIS METHOD OF GLIFLOZIN USING CONTINUOUS PROCESS
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Paragraph 0079; 0084-0087; 0093-0107, (2020/04/21)
The present invention relates to a method for gliflozin synthesis, comprising the steps of: (a) preparing a first product by making a stream comprising an initial reactant and a lactone react with a stream comprising n-Butyllithium; and (b) making the stream comprising the first product react with a stream comprising p-toluenesulfonic acid (PTSA) to produce a second product.COPYRIGHT KIPO 2020
Industrial preparation method for empagliflozin
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, (2017/08/27)
The invention discloses an industrial preparation method for empagliflozin. Specifically, the invention relates to a preparation method for empagliflozin as shown in formula as defined in the specification, i.e., (1S)-1,5-dehydro-1-(4-chloro-3{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}pheyl)-D-glucitol, and an intermediate prepared by using the method. The preparation method for empagliflozin in the invention is stable in process, good in reproducibility and suitable for large-scale production.