915369-04-9

Basic information

• Product Name: 3-Quinolinecarbonitrile, 6-bromo-4-[(3-chloro-4-fluorophenyl)amino]-
• CAS NO: 915369-04-9
• Molecular Formula: C16H8BrClFN3
• Molecular Weight: 376.615
• Mol File: 915369-04-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 6-bromo-4-[(3-chloro-4-fluorophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 6-bromo-4-[(3-chloro-4-fluorophenyl)amino]-(915369-04-9)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 6-bromo-4-[(3-chloro-4-fluorophenyl)amino]-(915369-04-9)

Safety Data

• Hazardous Substances Data: 915369-04-9(Hazardous Substances Data)

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 364793-54-4 6-bromo-4-chloro-3-quinolinecarbonitrile 
• 58286-26-3 ethyl (Z)-3-[(4-bromophenyl)amino]-2-cyanoprop-2-enoate 
• 106-40-1 4-bromo-aniline 
• 364793-52-2 6-bromo-4-hydroxyquinoline-3-carbonitrile 

Downstream Products

• 928779-61-7 4-(3-Chloro-4-fluoro-phenylamino)-6-((E)-styryl)-quinoline-3-carbonitrile 

Relevant articles and documents

Synthesis and photophysical properties of a fluorescent cyanoquinoline probe for profiling ERBB2 kinase inhibitor response

A fluorescent probe targeting the ERBB2 receptor tyrosine was designed, synthesized and evaluated as reporter of ERBB2 dynamics in overexpressing BT474, i.e. Her2(+), cells. Two cyanoquinazoline (CQ) probes modeled after type-I (CQ1) or active state and t

SMALL MOLECULE INHIBITORS OF EGFR AND PI3K

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.

3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as