91599-79-0

Basic information

• Product Name: (S)-1-BENZYL-3-HYDROXYPIPERIDINE
• Synonyms: (S)-N-BENZYL-3-HYDROXYPIPERIDINE;(S)-1-BENZYL-PIPERIDIN-3-OL;(S)-1-BENZYL-3-HYDROXYPIPERIDINE;(S)-1-BENZYL-PIPERIDINOL;(S)-1-N-BENZYL-3-HYDROXY-PIPERIDINE;3-PIPERIDINOL, 1-(PHENYLMETHYL)-, (3S)-;(S)-1-Benzyl-3-piperidinol;(S)-1-Benzyl-3-hydroxypiperidi
• CAS NO: 91599-79-0
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 91599-79-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 296.8°Cat760mmHg
• Flash Point: 113 °C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.000631mmHg at 25°C
• Refractive Index: n20/D 1.545±0.002
• Storage Temp.: 2-8°C
• PKA: 14.82±0.20(Predicted)
• CAS DataBase Reference: (S)-1-BENZYL-3-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-BENZYL-3-HYDROXYPIPERIDINE(91599-79-0)
• EPA Substance Registry System: (S)-1-BENZYL-3-HYDROXYPIPERIDINE(91599-79-0)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2810 6.1/PG 3
• Hazardous Substances Data: 91599-79-0(Hazardous Substances Data)

Usage

General Description

(S)-1-Benzyl-3-hydroxypiperidine is a chemical compound that belongs to the class of piperidines, which are organic compounds containing a six-membered ring structure with five carbon atoms and one nitrogen atom. (S)-1-BENZYL-3-HYDROXYPIPERIDINE is a chiral molecule, meaning it has a non-superimposable mirror image, and the (S)-enantiomer has a specific orientation of atoms around the chiral center. (S)-1-Benzyl-3-hydroxypiperidine has potential applications in pharmaceutical research as it is a building block for the synthesis of various biologically active molecules. It may also be used as a precursor for the production of certain medications and drug candidates. Additionally, its unique structure and properties make it of interest for further study in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2/t12-/m0/s1

Upstream product

• 24211-55-0 (S)-3-hydroxypiperidine 
• 100-44-7 benzyl chloride 
• 91599-81-4 (R)-N-benzyl-3-hydroxypiperidine 
• 40114-49-6 1-benzyl-3-piperidone 
• 100-46-9 benzylamine 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 14813-01-5 1-benzyl-3-hydroxypiperidine 
• 108-05-4 vinyl acetate 
• 1200404-98-3 rac-N-benzyl-3-piperidinyl butanoate 
• 174621-91-1 rac-N-benzyl-3-piperidinyl acetate 
• 108-22-5 Isopropenyl acetate 
• 344-25-2 D-Prolin 
• 100-39-0 benzyl bromide 
• 53912-80-4 (S)-N-benzylprolinol 

Downstream Products

• 625471-18-3 tert-butyl (3S)-3-aminopiperidine-1-carboxylate 
• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 
• 404577-34-0 (R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester 
• 85275-46-3 tert-butyl (3R)-3-(p-tolylsulfonyloxy)piperidine-1-carboxylate 
• 940890-90-4 (S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester 
• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 
• 119065-61-1 (R,S)-Benidipine 
• 119065-61-1 (S,S)-Benidipine 

Relevant articles and documents

Preparation method of piperidine alcohol compound

Discloses a preparation method of a piperidinol compound, wherein the piperidinol is selected from (R)-1 - benzyl -3 - piperidinol. 1 -benzyl -3 - piperidone as reaction raw material and application thereof LiAlH4 A chiral reagent formed by the

A Bruton tyrosine kinase (Btk) method for the preparation of

The invention relates to a preparation method of a Bruton's tyrosine kinase (Btk) intermediate (VI). The method comprises the following steps: carrying out benzylamine ring opening on a compound (S)-(+)-5-substituted-2-tetrahydrofurancarboxylic acid to obtain a product, and reacting the product with acyl chloride or acid anhydride to obtain a compound II; reducing the compound II, carrying out salt formation on the reduced compound II by using 1R-(-)-camphorsulfonic acid, and degrading the obtained salt to obtain a compound III; and reducing the compound III, carrying out salt formation on the reduced compound III and AcOH to obtain a compound V, and carrying out Boc addition on the compound V under an alkaline condition to obtain the target compound VI.

Chiral-1-tert-butoxy-carbonyl-3-hydroxy-piperidine, and the preparation of chiral turning method

The invention relates to preparation of chirality-1-t-butyloxycarboryl-3-hydroxy piperidine and a method for chirality turning. The preparation mainly comprises the following steps: resolving N-benzyl-3-hydroxy piperidine as a raw material to obtain a (S) or (R)-1-benzyl-3-hydroxy piperidine camphorsulfonic acid salt, performing alkali freedom to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine, performing palladium carbon hydrogenation debenzylation/t-butyloxycarboryl protection to obtain (S) or (R)-1-t-butyloxycarboryl-3-hydroxy piperidine, acylating substituting sulfonyl chloride of (R) or (S)-1-substituting-3-hydroxy piperidine as a raw material to obtain (R) or (S)-1-substituting-3-hydroxy piperidine sulfonate, substituting by using substituting carboxylate to obtain (S) or (R)-1-substituting-3-hydroxy piperidine carboxylic ester, and performing alkaline hydrolysis to obtain (S) or (R)-1-substituting-3-hydroxy piperidine. The synthesis route is gentle in reaction condition, and is applicable to industrial large-scale production.