916336-32-8

Basic information

• Product Name: Benzoic acid, 4-iodo-, 2-(4-nitrophenoxy)ethyl ester
• CAS NO: 916336-32-8
• Molecular Formula: C15H12INO5
• Molecular Weight: 413.168
• Mol File: 916336-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-iodo-, 2-(4-nitrophenoxy)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-iodo-, 2-(4-nitrophenoxy)ethyl ester(916336-32-8)
• EPA Substance Registry System: Benzoic acid, 4-iodo-, 2-(4-nitrophenoxy)ethyl ester(916336-32-8)

Safety Data

• Hazardous Substances Data: 916336-32-8(Hazardous Substances Data)

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 916336-23-7 4-((E)-2-Methoxycarbonyl-vinyl)-benzoic acid 2-(4-amino-phenoxy)-ethyl ester 
• 916336-33-9 4-((E)-2-Methoxycarbonyl-vinyl)-benzoic acid 2-(4-nitro-phenoxy)-ethyl ester 

Relevant articles and documents

4′-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents

Mitosis inhibitors are powerful anticancer drugs. Based on a novel anti-microtubule agent of 5-(4′-methoxy)anilino-4-hydroxy-8-nitroquinazoline, a series of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8- nitroquinazolines were designed and synthesized to investigate the effect of the substitution on the inhibitory activity against mitotic progression of tumor cells. The large alkoxyl substitution on the 4′-position of 5-anilino ring is beneficial for the potency. The 5-(3′,4′,5′-trimethoxy)anilino-8-nitroquinazoline (1h) displays an overwhelming activity in arresting the cells at the G2/M phase, providing a promising new template for further development of potent microtubule-targeted anti-mitotic drugs.