916452-54-5

Basic information

• Product Name: (3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone
• Synonyms: (3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone
• CAS NO: 916452-54-5
• Molecular Weight: 619.758
• Mol File: 916452-54-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone(916452-54-5)
• EPA Substance Registry System: (3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone(916452-54-5)

Safety Data

• Hazardous Substances Data: 916452-54-5(Hazardous Substances Data)

Upstream product

• 916452-44-3 (3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone 

Downstream Products

• 916452-55-6 tert-butoxycarbonylamino-acetic acid 4-{3-[3-isobutyl-10-(4-methoxy-benzyl)-2,5,9,12-tetraoxo-1-oxa-4,8,11-triaza-cyclohexadec-13-en-16-yl]-but-1-enyl}-benzyl ester 
• 916452-57-8 (3S,10R,16S)-16-{(1R)-3-[4-(chloromethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone 
• 916452-58-9 (3S,10R,16S)-16-((1S)-1-{(2R,3R)-3-[4-(chloromethyl)phenyl]oxiranyl}ethyl)-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone 

Relevant articles and documents

Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide

In order to increase metabolic stability and water solubility of arenastatin A, an extremely potent cytotoxic depsipeptide from the Okinawan marine sponge of Dysidea arenaria, several 15,20-triamide analogues with a polar substituent on the phenyl ring were synthesized. The 15,20-triamide analogues with a polar substituent (24, 30, and 31) showed increased solubility to MeOH and stronger cytotoxicity against KB cells in comparison with the parental 15,20-triamide analogue (2). Furthermore, the diethylamine analogue (30) exhibited in vivo anti-tumor activity against subcutaneously implanted murine sarcoma.