91656-99-4

Basic information

• Product Name: Silane, (6-bromo-1-hexynyl)trimethyl-
• Synonyms: (5-bromo-pent-1-ynyl)-trimehyl-silane;Silane,(6-bromo-1-hexynyl)trimethyl;(6-bromo-1-hexynyl)trimethylsilane;1-bromo-6-(trimethylsilyl)-5-hexyne;8-bromo-2,2-dimethyl-2-silaoct-3-yne;6-bromo-1-trimethylsilanyl-hexyne;1-trimethylsilyl-6-bromohex-1-yne
• CAS NO: 91656-99-4
• Molecular Formula: C9H17BrSi
• Molecular Weight: 233.223
• Mol File: 91656-99-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 71-74 °C(Press: 3 Torr)
• Density: 1.114±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Silane, (6-bromo-1-hexynyl)trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (6-bromo-1-hexynyl)trimethyl-(91656-99-4)
• EPA Substance Registry System: Silane, (6-bromo-1-hexynyl)trimethyl-(91656-99-4)

Safety Data

• Hazardous Substances Data: 91656-99-4(Hazardous Substances Data)

Upstream product

• 113964-33-3 (6-chlorohex-1-yn-1-yl)trimethylsilane 
• 60366-80-5 1-Trimethylsilyl[6-(oxacyclohex-2-yloxy)]hex-1-yne 
• 928-90-5 5-hexyl-1-ol 
• 131353-19-0 6-(trimethylsilyl)-5-hexynyl methanesulfonate 
• 115142-91-1 6-(trimethylsilyl)-5-hexyn-1-yl p-toluenesulfonate 
• 103437-52-1 6-trimethylsilanyl-hex-5-yn-1-ol 

Downstream Products

• 55860-92-9 (2-methyl-1-cyclohexen-1-yl)trimethylsilane 
• 17874-17-8 cyclohex-1-enyl-trimethyl-silane 
• 3844-94-8 1-(trimethylsilyl)-1-hexyne 
• 94012-71-2 trimethyl(6-iodo-1-hexynyl)silane 
• 94012-70-1 trimethyl(cyclopentylidenemethyl)silane 
• 122471-48-1 Trimethyl<(cyclopentylidene)iodomethyl>silane 
• 487578-82-5 [7-(3,5-dimethoxyphenyl-1,3-dithian-7-yl)-1-heptynyl]trimethylsilane 

Relevant articles and documents

[2+2+2]-Cycloaddition of 4-Hydroxy-Substituted Enediynes to 2-Hydroxy-Substituted Decahydrophenanthrenes

Enediynes rac-4 were prepared in seven steps with an overall yield of 31% starting from 4-pentyn-1-ol (5). A cobalt mediated [2+2+2]-cycloaddition of these enediynes and subsequent removal of the metal fragment afforded the decahydrophenanthrenes rac-3/13

A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling

Despite the known propensity of small-molecule electrophiles to react with numerous cysteine-active proteins, biological actions of individual signal inducers have emerged to be chemotype-specific. To pinpoint and quantify the impacts of modifying one target out of the whole proteome, we develop a target-protein-personalized "electrophile toolbox" with which specific intracellular targets can be selectively modified at a precise time by specific reactive signals. This general methodology, T-REX (targetable reactive electrophiles and oxidants), is established by (1) constructing a platform that can deliver a range of electronic and sterically different bioactive lipid-derived signaling electrophiles to specific proteins in cells; (2) probing the kinetics of targeted delivery concept, which revealed that targeting efficiency in cells is largely driven by initial on-rate of alkylation; and (3) evaluating the consequences of protein-target- and small-molecule-signal-specific modifications on the strength of downstream signaling. These data show that T-REX allows quantitative interrogations into the extent to which the Nrf2 transcription factor-dependent antioxidant response element (ARE) signaling is activated by selective electrophilic modifications on Keap1 protein, one of several redox-sensitive regulators of the Nrf2-ARE axis. The results document Keap1 as a promiscuous electrophile-responsive sensor able to respond with similar efficiencies to discrete electrophilic signals, promoting comparable strength of Nrf2-ARE induction. T-REX is also able to elicit cell activation in cases in which whole-cell electrophile flooding fails to stimulate ARE induction prior to causing cytotoxicity. The platform presents a previously unavailable opportunity to elucidate the functional consequences of small-molecule-signal- and protein-target-specific electrophilic modifications in an otherwise unaffected cellular background.

2-AMINOMETHYLALKYNYLALKYL-1,3-DITHIANE DERIVATIVES

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