916726-85-7

Basic information

• Product Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro((neopentyloxy)sulfonyl)methyl)phenyl)propanoic acid
• Synonyms: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro((neopentyloxy)sulfonyl)methyl)phenyl)propanoic acid
• CAS NO: 916726-85-7
• Molecular Weight: 587.641
• Mol File: 916726-85-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro((neopentyloxy)sulfonyl)methyl)phenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro((neopentyloxy)sulfonyl)methyl)phenyl)propanoic acid(916726-85-7)
• EPA Substance Registry System: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro((neopentyloxy)sulfonyl)methyl)phenyl)propanoic acid(916726-85-7)

Safety Data

• Hazardous Substances Data: 916726-85-7(Hazardous Substances Data)

Upstream product

• 110797-35-8 N-[(9-fluorenyl)methoxycarbonyl]-L-serine tert-butyl ester 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 345915-64-2 (4-iodophenyl)methanesulfonyl chloride 
• 16004-15-2 1-bromomethyl-4-iodobenzene 

Relevant articles and documents

Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogues and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogues for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallography.