917111-44-5 Usage
General Description
CYT997 is a novel vascular disrupting agent and tubulin polymerization inhibitor that has shown promising anti-tumor activity in preclinical studies. It is a synthetic compound derived from the natural product colchicine, and it works by targeting and disrupting the newly formed blood vessels that supply tumors, leading to their collapse and subsequent cell death. Additionally, CYT997 also inhibits microtubule assembly, which disrupts the cell cycle and leads to apoptosis. Preclinical studies have demonstrated potent antitumor activity against a variety of solid tumors and have shown potential for use in combination with other chemotherapeutic agents. Clinical trials are ongoing to evaluate the safety and efficacy of CYT997 in patients with advanced solid tumors.
Check Digit Verification of cas no
The CAS Registry Mumber 917111-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,7,1,1 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 917111-44:
(8*9)+(7*1)+(6*7)+(5*1)+(4*1)+(3*1)+(2*4)+(1*4)=145
145 % 10 = 5
So 917111-44-5 is a valid CAS Registry Number.
917111-44-5Relevant articles and documents
Discovery of CYT997: a structurally novel orally active microtubule targeting agent
Burns, Christopher J.,Harte, Michael F.,Bu, Xianyong,Fantino, Emmanuelle,Joffe, Max,Sikanyika, Harrison,Su, Stephen,Tranberg, C. Elisabet,Wilson, Neil,Charman, Susan A.,Shackleford, David M.,Wilks, Andrew F.
scheme or table, p. 4639 - 4642 (2010/04/28)
CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 a
