917389-26-5Relevant articles and documents
Asymmetric synthesis of letermovir using a novel phase-Transfer-catalyzed aza-michael reaction
Humphrey, Guy R.,Dalby, Stephen M.,Andreani, Teresa,Xiang, Bangping,Luzung, Michael R.,Song, Zhiguo Jake,Shevlin, Michael,Christensen, Melodie,Belyk, Kevin M.,Tschaen, David M.
, p. 1097 - 1103 (2017/01/16)
The development of a concise asymmetric synthesis of the antiviral development candidate letermovir is reported, proceeding in 60% yield over a total of seven steps from commercially available materials. Key to the effectiveness of this process is a nove