918161-10-1

Basic information

• Product Name: (R)-2-amino-N-(4-methoxy-benzyl)-3-phenyl-propionamide
• Synonyms: (R)-2-amino-N-(4-methoxy-benzyl)-3-phenyl-propionamide
• CAS NO: 918161-10-1
• Molecular Weight: 284.358
• Mol File: 918161-10-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-amino-N-(4-methoxy-benzyl)-3-phenyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-amino-N-(4-methoxy-benzyl)-3-phenyl-propionamide(918161-10-1)
• EPA Substance Registry System: (R)-2-amino-N-(4-methoxy-benzyl)-3-phenyl-propionamide(918161-10-1)

Safety Data

• Hazardous Substances Data: 918161-10-1(Hazardous Substances Data)

Upstream product

• 918161-12-3 (R)-2-azido-N-(4-methoxybenzyl)-3-phenyl-propionamide 
• 918161-08-7 (S)-2-hydroxy-N-(4-methoxybenzyl)-3-phenyl-propionamide 
• 918161-09-8 methanesulfonic acid (S)-1-(4-methoxy-benzylcarbamoyl)-2-phenyl-ethyl ester 
• 918161-14-5 (R)-2-hydroxy-N-(4-methoxybenzyl)-3-phenyl-propionamide 
• 918161-13-4 acetic acid (R)-1-(4-methoxy-benzylcarbamoyl)-2-phenyl-ethyl ester 
• 918161-15-6 acetic acid (S)-1-(4-methoxy-benzylcarbamoyl)-2-phenyl-ethyl ester 
• 63-91-2 L-phenylalanine 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 673-06-3 D-(R)-phenylalanine 
• 2448-45-5 Cbz-D-Phe 
• 28069-46-7 D-phenylalanine hydrochloride 

Relevant articles and documents

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

Multicomponent diversity and enzymatic enantioselectivity as a route towards both enantiomers of α-amino acids-a model study

A model study on a new, enantioconvergent method for the synthesis of chiral, nonracemic α-amino acids is presented. α-Acetoxyamides obtained in a Passerini multicomponent reaction are selectively hydrolyzed by Wheat Germ lipase. Studies on conversion of the thus obtained, enantiomerically enriched α-hydroxyamides into α-aminoamides are presented. Products of these reactions are then hydrolyzed to give α-amino acids.