918316-16-2

Basic information

• Product Name: 2-(1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazol-3-yl)-propan-2-ol
• Synonyms: 2-(1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazol-3-yl)-propan-2-ol
• CAS NO: 918316-16-2
• Molecular Weight: 473.016
• Mol File: 918316-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazol-3-yl)-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazol-3-yl)-propan-2-ol(918316-16-2)
• EPA Substance Registry System: 2-(1-(2-chloro-phenyl)-5-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-1H-pyrazol-3-yl)-propan-2-ol(918316-16-2)

Safety Data

• Hazardous Substances Data: 918316-16-2(Hazardous Substances Data)

Upstream product

• 5370-25-2 2-Acetyl-5-bromothiophene 
• 676-58-4 methylmagnesium chloride 

Relevant articles and documents

Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXRβ

A series of biaryl pyrazole and imidazole Liver X Receptor (LXR) partial agonists has been synthesized displaying LXRβ selectivity. The LXRβ selective partial agonist 18 was identified with potent induction of ATP binding transporters ABCA1 and ABCG1 in human whole blood (EC50 = 1.2 μM, 55% efficacy). In mice 18 displayed peripheral induction of ABCA1 at 3 and 10 mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist.