919103-45-0

Basic information

• Product Name: 6-Iodoxindole
• Synonyms: 6-Iodoxindole;6-Iodooxindole;1,3-Dihydro-6-iodo-2H-indol-2-one;6-Iodo-2-oxindole;6-Iodoindolin-2-one;6-iodo-1,3-dihydroindol-2-one
• CAS NO: 919103-45-0
• Molecular Formula: C₈H₆INO
• Molecular Weight: 259.041
• Mol File: 919103-45-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 365℃
• Flash Point: 174℃
• Appearance: /
• Density: 1.945
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Iodoxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Iodoxindole(919103-45-0)
• EPA Substance Registry System: 6-Iodoxindole(919103-45-0)

Safety Data

• Hazardous Substances Data: 919103-45-0(Hazardous Substances Data)

Usage

General Description

6-Iodoxindole is a chemical compound that belongs to the class of indole derivatives. It is an iodinated derivative of indole and is also known as 6-iodo-1H-indole. 6-Iodoxindole is commonly used as a precursor in organic synthesis and is also known for its potential pharmaceutical applications. It is a highly reactive compound due to the presence of the iodine atom, which makes it useful in a variety of chemical reactions. 6-Iodoxindole has been studied for its potential biological activities, including its role as a precursor in the synthesis of pharmaceuticals and its potential as a therapeutic agent in various diseases.

Upstream product

• 59-48-3 2-oxoindole 
• 88-73-3 2-Chloronitrobenzene 
• 1338507-93-9 diethyl 2-(4-iodo-2-nitrophen-1-yl)malonate 
• 1573120-04-3 dimethyl 2-(4-iodo-2-nitrophen-1-yl)malonate 
• 41252-95-3 1-chloro-4-iodo-2-nitrobenzene 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 

Downstream Products

• 919103-46-1 (2-Oxo-2,3-dihydro-1H-indol-6-ylsulfanyl)-benzoic acid 
• 1535204-25-1 C₂₃H₂₀IN₃O*ClH 
• 1535204-23-9 3-(hydroxy-phenyl-methylene)-6-iodo-1,3-dihydro-indol-2-one 
• 1537909-08-2 3-[(4-dimethylaminomethyl-phenylamino)-phenyl-methylene]-6-iodo-1,3-dihydro-indol-2-one 
• 919103-51-8 N-(2,5-Dimethyl-2H-pyrazol-3-yl)-2-(2-oxo-2,3-dihydro-1H-indol-6-ylsulfanyl)-benzamide 

Relevant articles and documents

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

PROCESS FOR PREPARING 6-IODO-2-OXINDOLE

Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.