92-02-4

Basic information

• Product Name: N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide
• Synonyms: n-[3-[bis(2-hydroxyethyl)amino]phenyl]-acetamid;N-(3-BIS(2-HYDROXYETHYL)AMINOPHENYL)ACETAMIDE;3'-[BIS(2-HYDROXYETHYL)AMINO]ACETANILIDE;3-(N,N-DIHYDROXYETHYL)AMINO ACETANILIDE;3-Dihydroxyethylamino-Acetanilide;3-Acetamido-N,N-bis-(2-hydroxyethyl)-aniline;3-N,N-DIHYDROXYETHYL AMINO ACETANILIDE 99%MIN;m-Aminoacetylaniline-dihydroxy
• CAS NO: 92-02-4
• Molecular Formula: C₁₂H₁₈N₂O₃
• Molecular Weight: 238.28
• EINECS: 202-117-4
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 92-02-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 111-115 °C(lit.)
• Boiling Point: 521.1 °C at 760 mmHg
• Flash Point: 269 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 1.1E-11mmHg at 25°C
• Refractive Index: 1.631
• PKA: 14.29±0.10(Predicted)
• CAS DataBase Reference: N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide(92-02-4)
• EPA Substance Registry System: N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide(92-02-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 92-02-4(Hazardous Substances Data)

Usage

General Description

N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide is a chemical compound that belongs to the class of acetamides. It is a derivative of phenylacetamide and contains a bis(2-hydroxyethylamino) group attached to the phenyl ring. N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and active pharmaceutical ingredients (APIs). It possesses potential therapeutic properties and has been studied for its antiviral, anticancer, and anti-inflammatory activities. Additionally, it can be utilized as a building block for the creation of novel compounds and drug candidates. Overall, N-(3-Bis(2-hydroxyethylamino)phenyl)acetamide is a versatile chemical with diverse applications in the field of drug discovery and development.

InChI:InChI=1/C12H18N2O3/c1-10(17)13-11-3-2-4-12(9-11)14(5-7-15)6-8-16/h2-4,9,15-16H,5-8H2,1H3,(H,13,17)

Upstream product

• 102-28-3 m-acetamide aniline 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 80751-19-5 N-{2-(4,6-Bis-dimethylamino-[1,3,5]triazin-2-ylazo)-5-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-acetamide 
• 1357264-40-4 N,N-bis-(2-hydroxyethyl)-m-phenylenediamine 
• 1357264-37-9 2-methacrylic acid 2-[[3-butyrylamino-4-(4-cyano-3-methylisothiazol-5-ylazo)-phenyl]-(2-(2-methacryloyloxy)ethyl)-amino]-ethyl ester 
• 1357264-34-6 acrylic acid 2-[[3-butyrylamino-4-(4-cyano-3-methylisothiazol-5-ylazo)-phenyl]-(2-acryloyloxyethyl)-amino]-ethyl ester 
• 1357264-33-5 N-[5-{bis-(2-hydroxyethyl)-amino}-2-(4-cyano-3-methylisothiazol-5-ylazo)-phenyl]-butyramide 
• 1357264-31-3 N-[3-{bis-(2-hydroxyethyl)-amino}-phenyl]-butyramide 
• 1357264-27-7 acrylic acid 2-[{3-acetylamino-4-(4-cyano-3-methylisothiazol-5-ylazo)-phenyl}-{2-acryloyloxyethyl}-amino]-ethyl ester 
• 1357264-25-5 3-chloropropionic acid 2-[{3-acetylamino-4-(4-cyano-3-methylisothiazol-5-ylazo)-phenyl}-{2-(3-chloropropionyloxy)-ethyl}-amino]-ethyl ester 
• 1357264-08-4 2-methacrylic acid 2-{[3-acetylamino-4-(4-cyano-3-methylisothiazol-5-ylazo)-phenyl]-[2-(2-methacryloyloxy)-ethyl]-amino}-ethyl ester 
• 1357264-93-7 2,2'-(3-acetamido-4-((2,6-dicyano-4-nitrophenyl)diazenyl)phenylazanediyl)bis(ethane-2,1-diyl)bis(2-methylacrylate) 
• 1357264-92-6 N-(5-(bis(2-hydroxyethyl)amino)-2-((2,6-dicyano-4-nitrophenyl)diazenyl)phenyl)-acetamide 
• 71500-42-0 1-amino-3-[bis(2'-hydroxyethyl)amino]benzene 
• 1357264-57-3 N-(5-(bis(2-hydroxyethyl)amino)-2-((2,6-dibromo-4-butylphenyl)diazenyl)phenyl)-acetamide 
• 14071-35-3 N-{5-(bis(2-hydroxyethyl)amino)-2-[(2-bromo-6-cyano-4-nitrophenyl)azo]phenyl}acetamide 

Relevant articles and documents

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.