92-55-7Relevant articles and documents
Synthetic method for medical intermediate 5-nitrofurfural diacetate
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Paragraph 0018-0066, (2019/03/25)
The invention relates to a production technology for 5-nitrofurfural diacetate. A main improvement point of the method is an adding moment and an adding mode of sulfuric acid. Through optimizing, a yield of the 5-nitrofurfural diacetate is improved, and higher purity is kept.
Preparation and Characterization of a Small Library of Thermally-Labile End-Caps for Variable-Temperature Triggering of Self-Immolative Polymers
Taimoory, S. Maryamdokht,Sadraei, S. Iraj,Fayoumi, Rose Anne,Nasri, Sarah,Revington, Matthew,Trant, John F.
supporting information, p. 4427 - 4440 (2018/04/26)
The reaction between furans and maleimides has increasingly become a method of interest as its reversibility makes it a useful tool for applications ranging from self-healing materials, to self-immolative polymers, to hydrogels for cell culture and for the preparation of bone repair. However, most of these applications have relied on simple monosubstituted furans and simple maleimides and have not extensively evaluated the potential thermal variability inherent in the process that is achievable through simple substrate modification. A small library of cycloadducts suitable for the above applications was prepared, and the temperature dependence of the retro-Diels-Alder processes was determined through in situ 1H NMR analyses complemented by computational calculations. The practical range of the reported systems ranges from 40 to >110 °C. The cycloreversion reactions are more complex than would be expected based on simple trends expected based on frontier molecular orbital analyses of the materials.
Sulphated zirconia as an eco-friendly catalyst in acylal preparation under solvent-free conditions, acylal deprotection assisted by microwaves, and the synthesis of anhydro-dimers of o-hydroxybenzaldehydes
Palacios-Grijalva, Laura Nadxieli,Cruz-Gonzalez, Deysi Y.,Lomas-Romero, Leticia,Gonzalez-Zamora, Eduardo,Ulibarri, Gerardo,Negron-Silva, Guillermo E.
experimental part, p. 4065 - 4078 (2010/03/01)
A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.
