920509-13-3

Basic information

• Product Name: (3-chloro-4-hydroxy-5-methylphenyl)acetic acid
• Synonyms: (3-chloro-4-hydroxy-5-methylphenyl)acetic acid
• CAS NO: 920509-13-3
• Molecular Weight: 200.622
• Mol File: 920509-13-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3-chloro-4-hydroxy-5-methylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloro-4-hydroxy-5-methylphenyl)acetic acid(920509-13-3)
• EPA Substance Registry System: (3-chloro-4-hydroxy-5-methylphenyl)acetic acid(920509-13-3)

Safety Data

• Hazardous Substances Data: 920509-13-3(Hazardous Substances Data)

Usage

General Description

(3-chloro-4-hydroxy-5-methylphenyl)acetic acid is a chemical compound with the molecular formula C9H9ClO3. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (3-chloro-4-hydroxy-5-methylphenyl)acetic acid is a derivative of acetic acid and contains a hydroxyl group, a methyl group, and a chlorine atom attached to a phenyl ring. It can be used as a building block in organic synthesis to create more complex molecules. In addition, it has potential applications in the development of new drugs and crop protection products. Overall, (3-chloro-4-hydroxy-5-methylphenyl)acetic acid is a versatile compound with various uses in the fields of chemistry and medicine.

Upstream product

• 82965-44-4 2-chloro-4-dimethylaminomethyl-6-methylphenol 
• 87-64-9 2-chloro-6-methylphenol 
• 920509-12-2 (3-chloro-4-hydroxy-5-methylphenyl)acetonitrile 

Downstream Products

• 920509-14-4 (3-chloro-4-hydroxy-5-methylphenyl)acetic acid methyl ester 
• 920509-15-5 [3-chloro-4-(6-chloro-5-isopropylpyridazin-3-yloxy)-5-methylphenyl]acetic acid methylester 
• 920509-16-6 [3-chloro-4-(6-chloro-5-isopropylpyridazin-3-yloxy)-5-methylphenyl]acetic acid 

Relevant articles and documents

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3- yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogues. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclinical model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 weeks.