921204-93-5

Basic information

• Product Name: (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate
• Synonyms: (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate
• CAS NO: 921204-93-5
• Molecular Weight: 537.502
• Mol File: 921204-93-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate(921204-93-5)
• EPA Substance Registry System: (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate(921204-93-5)

Safety Data

• Hazardous Substances Data: 921204-93-5(Hazardous Substances Data)

Upstream product

• 124980-98-9 (R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate 
• 676517-45-6 4-(3,4-dichloro-2-methylphenoxy)-1-(piperidin-4-ylmethyl)-piperidine 
• 73283-54-2 (S)-methyl 2-amino-3-(4-fluorophenyl)propanoate 

Relevant articles and documents

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

CHEMICAL COMPOUNDS

The present invention provides a compound of a formula (I) wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.