921223-74-7Relevant articles and documents
Probing structural effects on replication efficiency through comparative analyses of families of potential self-replicators
Kassianidis, Eleftherios,Pearson, Russell J.,Philp, Douglas
, p. 8798 - 8812 (2006)
A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship be tween molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.