92138-35-7

Basic information

• Product Name: 2-Hydroxy-3-Nitro-6-Chloropyridine
• Synonyms: 2-Hydroxy-3-Nitro-6-Chloropyridine;6-Chloro-3-nitropyridin-2-ol;6-Chloro-3-nitro-pyridine-2-one;2-hydroxy-3-nitro-6-cloropyridine;6-chloro-3-nitropyridin-2(1H)-one;6-Chloro-3-nitro-2(1H)-pyridinone;2(1H)-Pyridinone,6-chloro-3-nitro-;6-chloro-3-nitro-1H-pyridin-2-one
• CAS NO: 92138-35-7
• Molecular Formula: C₅H₃ClN₂O₃
• Molecular Weight: 174.54192
• Product Categories: Pyridine
• Mol File: 92138-35-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 313.2 °C at 760 mmHg
• Flash Point: 143.2 °C
• Appearance: /
• Density: 1.61 g/cm³
• Vapor Pressure: 0.000503mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.68±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-3-Nitro-6-Chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3-Nitro-6-Chloropyridine(92138-35-7)
• EPA Substance Registry System: 2-Hydroxy-3-Nitro-6-Chloropyridine(92138-35-7)

Safety Data

• HazardClass: IRRITANT, TOXIC
• Hazardous Substances Data: 92138-35-7(Hazardous Substances Data)

Usage

Chemical Properties

Brownish yellow powder

InChI:InChI=1/C5H3ClN2O3/c6-4-2-1-3(8(10)11)5(9)7-4/h1-2H,(H,7,9)

Upstream product

• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 

Downstream Products

• 186413-77-4 6-chloro-3-nitro-2-(propan-2-yloxy)pyridine 
• 353293-50-2 2-(Benzyloxy)-6-chloro-3-nitropyridine 
• 33630-99-8 3-amino-2-pyridone 
• 39258-93-0 3-nitro-6-phenylpyridin-2(1H)-one 
• 1313881-70-7 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine 
• 1313881-69-4 tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate 
• 1439394-28-1 tert-butyl (1-(4-((3-nitro-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 187242-88-2 2-chloro-3-nitro-6-phenylpyridine 
• 1439394-30-5 tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 186413-94-5 N-(6-Dimethoxymethyl-4-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-2,2-dimethyl-propionamide 
• 186413-93-4 N-(6-Formyl-4-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-2,2-dimethyl-propionamide 
• 475272-86-7 Methyl 6-(benzyloxy)-5-{[(6-(benzyloxy)-5-{[(6-(benzyloxy)-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-2-pyridinecarboxylate 
• 475272-88-9 Methyl 6-(benzyloxy)-5-{[(6-(benzyloxy)-5-{[(6-isopropoxy-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-2-pyridinecarboxylate 
• 475272-87-8 Methyl 5-{[(6-(benzyloxy)-5-{[(6-isopropoxy-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-6-isopropoxy-2-pyridine carboxylate 

Relevant articles and documents

5-6-BICYCLIC HETEROAROMATIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

Design and application of an α-helix-mimetic scaffold based on an oligoamide-foldamer strategy: Antagonism of the Bak BH3/Bcl-xL complex

The prevention of cell death by the antiapoptotic protein Bcl-xL has been linked to a number of cancers. Bcl-xl binds to the BH3 domain of the proapoptotic protein Bak, thus preventing programmed cell death. A competitive assay and docking studies have shown that the polyamide scaffold 1, which was synthesized based on a rational structure-based design, interferes with the Bak BH3/Bcl-xl complexation.