921617-79-0

Basic information

• Product Name: (R,S)-2-[4-(5-p-methylphenyl-3-trifluoromethyl-pyrazol-1-yl)-benzensulfonylamino-oxy]-propionic acid
• CAS NO: 921617-79-0
• Molecular Weight: 469.441
• Mol File: 921617-79-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R,S)-2-[4-(5-p-methylphenyl-3-trifluoromethyl-pyrazol-1-yl)-benzensulfonylamino-oxy]-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-2-[4-(5-p-methylphenyl-3-trifluoromethyl-pyrazol-1-yl)-benzensulfonylamino-oxy]-propionic acid(921617-79-0)
• EPA Substance Registry System: (R,S)-2-[4-(5-p-methylphenyl-3-trifluoromethyl-pyrazol-1-yl)-benzensulfonylamino-oxy]-propionic acid(921617-79-0)

Safety Data

• Hazardous Substances Data: 921617-79-0(Hazardous Substances Data)

Upstream product

• 2786-22-3 2-(aminooxy)propanoic acid 
• 190711-56-9 4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride 
• 4703-02-0 2-(aminooxy)propanoic acid hydrochloride 

Relevant articles and documents

New celecoxib derivatives as anti-inflammatory agents

A series of 1,5-diarylpyrazoles with a substituted benzenesulfonamide moiety was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Some compounds, for example, (±)-2-[4-(5-p-tolyl-3- trifluoromethyl-pyrazole-1-yl)-benzenesulfonylaminooxy]-propionic acid 16 and its disodium salt 21, had a higher in vivo anti-inflammatory activity compared to celecoxib, despite having no in vitro COX-1 or COX-2 inhibitory activity. Their gastrointestinal side effect profile is essentially more favorable than that of celecoxib.