923289-36-5

Basic information

• Product Name: Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-
• Synonyms: Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-;6-ACETYL-2-CHLORO-3-METHOXY ANILINE;1-(2-Amino-3-chloro-4-methoxyphenyl)ethanone;(2-Amino-3-chloro-4-methoxyphenyl)acetone;1-(2-Amino-3-chloro-4-methoxyphenyl)ethan-1-one, 6-Acetyl-2-chloro-3-methoxyaniline, 4-Acetyl-3-amino-2-chloroanisole;2'-Amino-3'-chloro-4'-methoxyacetophenone;1-(2-aMino-3-chloro-4-Methoxyphenyl)ethan-1-one;1-(2-Amino-3-chloro-4-methoxyphenyl)
• CAS NO: 923289-36-5
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.63
• Product Categories: Drug Intermediates;API intermediates
• Mol File: 923289-36-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 366.8ºC at 760 mmHg
• Flash Point: 175.6ºC
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-(923289-36-5)
• EPA Substance Registry System: Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-(923289-36-5)

Safety Data

• Hazardous Substances Data: 923289-36-5(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-, also known as ACMP, is a chemical compound used in pharmaceutical research and development. It is a synthetic intermediate that is being studied for its potential therapeutic applications, particularly in the field of cancer treatment. ACMP is a derivative of 3-chloro-4-methoxyaniline and is often used in the synthesis of various bioactive molecules. Its unique chemical structure and properties make it a valuable tool in the discovery of new drugs and treatments for a variety of medical conditions.

InChI:InChI=1/C9H10ClNO2/c1-5(12)6-3-4-7(13-2)8(10)9(6)11/h3-4H,11H2,1-2H3

Upstream product

• 75-05-8 acetonitrile 
• 113206-03-4 2-chloro-3-methoxyphenylamine 

Downstream Products

• 1180496-15-4 N-(6-acetyl-2-chloro-3-methoxyphenyl)-2-(trifluoromethyl)thiazole-4-carboxamide 
• 1180495-62-8 N-(6-acetyl-2-chloro-3-methoxyphenyl)-5-isopropylisoxazole-3-carboxamide 
• 1180495-68-4 N-(6-acetyl-2-chloro-3-methoxyphenyl)-2-isopropylthiazole-4-carboxamide 
• 1098189-05-9 2-isopropylamino-thiazole-4-carboxylic acid [6-acetyl-2-chloro-3-(2,2-dimethoxy-ethoxy)phenyl]amide 
• 1098189-15-1 vedroprevir 
• 1310551-61-1 6-Isopropyl-pyridine-2-carboxylic acid [6-acetyl-2-chloro-3-(2-methoxy-ethoxy)-phenyl]-amide 
• 1098201-26-3 1-[2-amino-3-chloro-4-(2-methoxy-ethoxy)-phenyl]-ethanone 
• 1310551-56-4 4-Isopropyl-thiazole-2-carboxylic acid [6-acetyl-2-chloro-3-(2,2-dimethoxy-ethoxy)-phenyl]-amide 
• 1310551-52-0 2-Isopropyl-thiazole-4-carboxylic acid [6-acetyl-2-chloro-3-(2,2-dimethoxy-ethoxy)-phenyl]-amide 
• 1098189-01-5 1-[2-amino-3-chloro-4-(2,2-dimethoxy-ethoxy)-phenyl]-ethanone 
• 1098189-00-4 1-(2-amino-3-chloro-4-hydroxy-phenyl)-ethanone 
• 1180496-00-7 N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-bromothiazole-2-carboxamide 
• 1180496-29-0 N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-cyclopropylthiazole-2-carboxamide 
• 1180495-36-6 N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamide 

Relevant articles and documents

Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

SAR analysis performed with a limited set of cyclopentane-containing macrocycles led to the identification of N-[17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]- 13-methyl-2,14-dioxo-3,13-diazatricyclo [13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamid e (TMC435350, 32c) as a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). TMC435350 also displayed low in vitro clearance and high permeability, which were confirmed by in vivo pharmacokinetic studies. TMC435350 is currently being evaluated in the clinics.

MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents ; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.