923590-95-8

Basic information

• Product Name: 4-BROMO-ISOINDOLINE HCL
• Synonyms: 4-BROMO-ISOINDOLINE HCL;3-Bromo-1H-isoindoline Hydrochloride;4-Bromo-1H-isoindoline hydrochloride;4-Bromo-2,3-dihydro-1H-isoindole hydrochloride;5-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridinecarboxylic acid;1H-Isoindole, 4-bromo-2,3-dihydro-, hydrochloride (1:1)
• CAS NO: 923590-95-8
• Molecular Formula: C₈H₈BrN*ClH
• Molecular Weight: 234.52
• EINECS: 1312995-182-4
• Product Categories: Building Blocks/Intermediates
• Mol File: 923590-95-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 269-274°C
• Appearance: White to pale yellow/Crystalline Powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-ISOINDOLINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-ISOINDOLINE HCL(923590-95-8)
• EPA Substance Registry System: 4-BROMO-ISOINDOLINE HCL(923590-95-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 923590-95-8(Hazardous Substances Data)

Usage

Uses

4-Bromoisoindoline Hydrochloride is used in preparation of of Isoindolines as HDAC inhibitors.

Upstream product

• 1035235-27-8 tert-butyl 4-bromo-2,3-dihydro-1H-isoindole-2-carboxylate 
• 127168-82-5 3-bromo-1,2-bis(bromomethyl)benzene 
• 576-23-8 2,3-dimethylbromobenzene 
• 50893-53-3 carbonochloridic acid 1-chloro-ethyl ester 
• 1170994-04-3 4-bromo-N-benzylisoindoline pTSA salt 
• 6952-59-6 3-cyanobromobenzene 
• 1372882-57-9 C₈H₆BrNO₂ 
• 923590-78-7 2-benzyl-4-bromoisoindoline 
• 337536-15-9 4-bromo-2,3-dihydro-isoindol-1-one 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 923590-92-5 2-benzyl-4-bromoisoindoline hydrochloride 

Downstream Products

• 923591-06-4 methyl (1R,21S,24S)-21-tert-butyl-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.1(4,7).0(6,11)]heptacosa-6,8,10-triene-24-carboxylate 
• 1332832-22-0 C₃₀H₄₃N₃O₇ 
• 1269195-05-2 1-benzyl 2-methyl (2S,4R)-4-((4-bromoisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate 
• 1035235-28-9 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT

The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R1, R2, R3, R4, R6

PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS

The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.

Synthesis of vaniprevir (MK-7009): Lactamization to prepare a 22-membered macrocycle

Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamization. Ri