92408-01-0

Basic information

• Product Name: [1-(4-CHLORO-BENZYL)-2-METHYL-1H-INDOL-3-YL]-METHANOL
• Synonyms: [1-(4-CHLORO-BENZYL)-2-METHYL-1H-INDOL-3-YL]-METHANOL;1-[(4-CHLOROPHENYL)METHYL]-2-METHYL-1H-INDOLE-3-METHANOL;1H-INDOLE-3-METHANOL, 1-[(4-CHLOROPHENYL)METHYL]-2-METHYL-
• CAS NO: 92408-01-0
• Molecular Formula: C₁₇H₁₆ClNO
• Molecular Weight: 285.77
• Mol File: 92408-01-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1-(4-CHLORO-BENZYL)-2-METHYL-1H-INDOL-3-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-CHLORO-BENZYL)-2-METHYL-1H-INDOL-3-YL]-METHANOL(92408-01-0)
• EPA Substance Registry System: [1-(4-CHLORO-BENZYL)-2-METHYL-1H-INDOL-3-YL]-METHANOL(92408-01-0)

Safety Data

• Hazardous Substances Data: 92408-01-0(Hazardous Substances Data)

Usage

General Description

The chemical "[1-(4-chloro-benzyl)-2-methyl-1H-indol-3-yl]-methanol" is a compound with a molecular structure containing a benzyl group, a chloro substituent, a methyl group, and an indolyl unit. It is a member of the indole class of compounds and has a methanol functional group attached. This chemical may have potential biological or pharmacological activity due to its structural features and may be used in pharmaceutical research or drug development. It is important to handle this chemical with care and follow appropriate safety precautions due to its potential reactivity and toxicity.

Upstream product

• 92407-86-8 1-(4-chlorobenzyl)-3-formyl-2-methyl-1H-indole 
• 95-20-5 2-methyl-1H-indole 
• 5416-80-8 2-methyl-1H-indole-3-carbaldehyde 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant articles and documents

Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

A series of 1-benzyl-3-(imidazol-1-ylmethyl)indole derivatives 35-46 were prepared under mild reaction conditions and tested for their antifungal activity. Pharmacomodulation at N1, C2 and C5 of the indole ring and at the level of the alkyl chain (R1) was carried out starting from the corresponding 3-acylindoles 6, 7 or 3-formylindoles 11-22. Target imidazolyl compounds 35-46 were obtained in satisfactory yields by CO2 elimination from the intermediate carbamates. All of the compounds were evaluated in vitro against two human fungal pathogens, Candida albicans (CA980001) and Aspergillus fumigatus (AF980003); amphotericin B, fluconazole and itraconazole were used as references. Seven out of 27 compounds (35b, 35e, 35g, 35h, 36a, 38a and especially 40a) exerted significant antifungal activity against C. albicans, with MIC in the range of 1-6 μg mL-1. As regards inhibitory activity against A. fumigatus, the MIC figures of most of our compounds were in excess of 20 μg mL-1 in contrast to the reference drugs, amphotericin B and itraconazole, whose MIC90 and MIC80 values were 0.14 and 0.50 μg mL-1, respectively. The most potent compound, 45a, exhibited MIC value (8±1 μg mL-1) 16-fold higher than that of itraconazole.