924898-11-3

Basic information

• Product Name: LY2157299 int 1
• Synonyms: LY2157299 int 1;4-(2-(6-methylpyridin-2-yl)-2-oxoethyl)quinoline-6-carbonitrile;2-(6-Cyanoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethanone;4-[2-(6-Methyl-2-pyridinyl)-2-oxoethyl]-6-quinolinecarbonitrile;4-(2-(6-METHYLPYRIDIN-2-YL)-2-OXOETHYL)QUINOLINE-6-CARBONITRILE(WXG02078)
• CAS NO: 924898-11-3
• Molecular Formula: C18H13N3O
• Molecular Weight: 287.31532
• EINECS: -0
• Mol File: 924898-11-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: LY2157299 int 1(CAS DataBase Reference)
• NIST Chemistry Reference: LY2157299 int 1(924898-11-3)
• EPA Substance Registry System: LY2157299 int 1(924898-11-3)

Safety Data

• Hazardous Substances Data: 924898-11-3(Hazardous Substances Data)

Usage

General Description

LY2157299 is an orally bioavailable, small-molecule inhibitor of the transforming growth factor beta (TGF-β) receptor type I kinase. It is being studied for its potential as a therapeutic agent in various types of cancer, including pancreatic, breast, and colorectal cancers, as well as in fibrotic diseases. As a TGF-β receptor inhibitor, LY2157299 works by blocking the signaling pathway that is involved in tumor growth and progression, as well as in the development of fibrosis. Preclinical studies have shown promising results, and clinical trials are ongoing to further evaluate the safety and efficacy of LY2157299 int 1 as a potential treatment for cancer and fibrotic diseases.