92534-73-1

Basic information

• Product Name: 1H-Pyrazole-5-carboxamide,4-amino-1-methyl-(9CI)
• Synonyms: 1H-Pyrazole-5-carboxamide,4-amino-1-methyl-(9CI);4-amino-1-methyl-1H-pyrazole-5-carboxamide(SALTDATA: FREE);4-amino-2-methylpyrazole-3-carboxamide
• CAS NO: 92534-73-1
• Molecular Formula: C₅H₈N₄O
• Molecular Weight: 140.145
• Product Categories: AMIDE
• Mol File: 92534-73-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 355.1°C at 760 mmHg
• Flash Point: 168.6°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 3.2E-05mmHg at 25°C
• Refractive Index: 1.695
• CAS DataBase Reference: 1H-Pyrazole-5-carboxamide,4-amino-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carboxamide,4-amino-1-methyl-(9CI)(92534-73-1)
• EPA Substance Registry System: 1H-Pyrazole-5-carboxamide,4-amino-1-methyl-(9CI)(92534-73-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 92534-73-1(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-5-carboxamide, 4-amino-1-methyl-(9CI), also known as Methyl 4-amino-1-methyl-1H-pyrazole-5-carboxylate, is an organic compound with the molecular formula C6H8N4O. It is a white solid, and is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The compound is known for its potential applications as a bioactive compound, with studies indicating its possible use in the treatment of various diseases. It is important to handle this compound with care, as it may present hazards to human health and the environment if mishandled.

InChI:InChI=1/C5H8N4O/c1-9-4(5(7)10)3(6)2-8-9/h2H,6H2,1H3,(H2,7,10)

Upstream product

• 1006962-20-4 1-methyl-4-nitro-1H-pyrazole-5-carbonyl chloride 
• 309740-49-6 methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate 
• 92534-69-5 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 694-31-5 1,5-dimethyl-1H-pyrazole 
• 92534-72-0 1-methyl-4-nitro-1H-pyrazole-5-carboxamide 

Downstream Products

• 83824-38-8 1-methylpyrazolo[4,3-d]pyrimidine-5,7-diol 
• 83824-38-8 1-methyl-1H-pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)-dione 
• 1285500-14-2 1-(4-(7-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)-3-ethylurea 
• 1285500-13-1 (S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea 
• 1285500-09-5 (S)-1-ethyl-3-(4-(1-methyl-7-(3-methylmorpholino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea 
• 1357086-91-9 8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 1357086-88-4 5-cyclohexylamino-8-(furan-2-yl)-1-methyl-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 939979-32-5 5,7-dichloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine 
• 1357086-75-9 5-{[(4-methoxy-phenyl)carbamoyl]amino}-8-(furan-2-yl)-1-methyl-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine 

Relevant articles and documents

DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

A series of N-7-methyl-imidazolopyrimidine inhibitors of the mTOR kinase have been designed and prepared, based on the hypothesis that the N-7-methyl substituent on imidazolopyrimidine would impart selectivity for mTOR over the related PI3Kα and δ kinases. The corresponding N-Me substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines also show potent mTOR inhibition with selectivity toward both PI3α and δ kinases. The most potent compound synthesized is pyrazolo[4,3-d]pyrimidine 21c. Compound 21c shows a Ki of 2 nM against mTOR inhibition, remarkable selectivity (>2900×) over PI3 kinases, and excellent potency in cell-based assays.

PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES

The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particular