926192-55-4Relevant articles and documents
Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping
Brouillette, Wayne J.,Atigadda, Venkatram R.,Ming, Luo,Air, Gillian M.,Babu, Yarlagadda S.,Bantia, Shanta
, p. 1901 - 1906 (1999)
A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3- guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.