926291-64-7

Basic information

• Product Name: CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester
• Synonyms: CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester;(R)-t-butyl (1-(3-chlorophenyl)-2-hydroxyethyl)carbamate;(R)-tert-Butyl (1-(3-chlorophenyl)-2-hydroxyethyl)carbamate;TERT-BUTYL (R)-(1-(3-CHLOROPHENYL)-2-HYDROXYETHYL)CARBAMATE
• CAS NO: 926291-64-7
• Molecular Formula: C₁₃H₁₈ClNO₃
• Molecular Weight: 271.73992
• Mol File: 926291-64-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester(926291-64-7)
• EPA Substance Registry System: CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester(926291-64-7)

Safety Data

• Hazardous Substances Data: 926291-64-7(Hazardous Substances Data)

Usage

Description

CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester is a chemical compound with the molecular formula C16H23ClO3. It is an ester derivative of CarbaMic acid, featuring a chlorine atom, a hydroxyl group, and a phenyl ring in its structure.
Used in Pharmaceutical Industry:
CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester is used as a synthetic intermediate for the production of pharmaceuticals. Its unique structure, including the chlorine atom and hydroxyl group, allows it to be a key component in the synthesis of various medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester serves as a synthetic intermediate in the development of agrochemicals. Its potential applications in this field may include the creation of pesticides or other agricultural products that can enhance crop protection and yield.
Used in Research and Development:
CarbaMic acid, N-[(1R)-1-(3-chlorophenyl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester may also have potential applications in research and development. Its specific uses and properties in this area would need to be determined through further investigation and testing, potentially leading to new discoveries and applications in various scientific fields.

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 2039-85-2 3-Chlorostyrene 

Downstream Products

• 926291-75-0 (R)-t-butyl (2-amino-1-(3-chlorophenyl)ethyl)carbamate 

Relevant articles and documents

Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: Potent inhibitors of R5 HIV-1 replication

The redesign of the previously reported thiophene-3-yl-methyl urea series, as a result of potential cardiotoxicity, was successfully accomplished, resulting in the identification of a novel potent series of CCR5 antagonists containing the imidazolidinylpiperidinyl scaffold. The main redesign criteria were to reduce the number of rotatable bonds and to maintain an acceptable lipophilicity to mitigate hERG inhibition. The structure-activity relationship (SAR) that was developed was used to identify compounds with the best pharmacological profile to inhibit HIV-1. As a result, five advanced compounds, 6d, 6e, 6i, 6h, and 6k, were further evaluated for receptor selectivity, antiviral activity against CCR5 using (R5) HIV-1 clinical isolates, and in vitro and in vivo safety. On the basis of these results, 6d and 6h were selected for further development.

CHEMOKINE RECEPTOR BINDING COMPOUNDS

The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).