926622-88-0

Basic information

• Product Name: (5S)-5-cyclohexyl-2-Pyrrolidinone
• Synonyms: (5S)-5-cyclohexyl-2-Pyrrolidinone
• CAS NO: 926622-88-0
• Molecular Formula: C10H17NO
• Molecular Weight: 167.24808
• Mol File: 926622-88-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 71-73 °C
• Boiling Point: 330.2±11.0 °C(Predicted)
• Appearance: /
• Density: 1.036±0.06 g/cm3(Predicted)
• PKA: 16.62±0.40(Predicted)
• CAS DataBase Reference: (5S)-5-cyclohexyl-2-Pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (5S)-5-cyclohexyl-2-Pyrrolidinone(926622-88-0)
• EPA Substance Registry System: (5S)-5-cyclohexyl-2-Pyrrolidinone(926622-88-0)

Safety Data

• Hazardous Substances Data: 926622-88-0(Hazardous Substances Data)

Usage

Description

(5S)-5-cyclohexyl-2-Pyrrolidinone, a chemical compound with the molecular formula C10H17NO, is a cyclic amide featuring a pyrrolidinone ring and a cyclohexyl group attached to the 5th position. (5S)-5-cyclohexyl-2-Pyrrolidinone is recognized for its stereochemistry and has garnered interest as a potential chiral auxiliary in organic reactions.

Uses

Used in Pharmaceutical Industry:
(5S)-5-cyclohexyl-2-Pyrrolidinone is used as a building block for the synthesis of various drugs, contributing to the development of new pharmaceuticals due to its unique structural properties.
Used in Agrochemical Industry:
In the agrochemical sector, (5S)-5-cyclohexyl-2-Pyrrolidinone serves as an intermediate in the synthesis of pesticides, playing a crucial role in the creation of effective and targeted pest control solutions.
Used as a Solvent:
(5S)-5-cyclohexyl-2-Pyrrolidinone is also utilized as a solvent in organic synthesis, facilitating various chemical reactions and processes in the laboratory and industrial settings.
Used as a Chiral Auxiliary:
Due to its stereochemistry, (5S)-5-cyclohexyl-2-Pyrrolidinone has been studied for its potential as a chiral auxiliary in organic reactions, which could lead to advancements in asymmetric synthesis and the production of enantiomerically pure compounds.

Upstream product

• 1012369-67-3 (R)-tert-butyl 2-cyclohexyl-5-oxopyrrolidine-1-carboxylate 
• 1318249-50-1 C₁₉H₂₉NO₇ 
• 1318249-52-3 C₁₉H₃₁NO₆ 
• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 872357-86-3 (R)-(+)-N,N-dibenzyl-N-(1-cyclohexyl-2-propynyl)amine 
• 872357-80-7 (R)-(+)-N,N-dibenzyl-N-[1-cyclohexyl-3-(trimethylsilyl)-2-propynyl]amine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 926622-74-4 (S)-ethyl 4-cyclohexyl-4-(hydroxy((R)-1-(2,4,6-triisopropylphenyl)ethyl)amino)butanoate 
• 872357-94-3 ethyl 4-cyclohexyl-4-(dibenzylamino)-2-butynoate 
• 3218-02-8 cyclohexylmethylamine 
• 123-56-8 Succinimide 
• 931-50-0 cyclohexylmagnesium bromide 
• 926622-67-5 (R,Z)-N-(cyclohexylmethylene)-1-(2,4,6-triisopropylphenyl)ethanamine N-oxide 

Relevant articles and documents

Photocatalytic α-Tertiary Amine Synthesis via C?H Alkylation of Unmasked Primary Amines

A practical, catalytic entry to α,α,α-trisubstituted (α-tertiary) primary amines by C?H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100 percent atom-economy. Our strategy, which uses an organic photocatalyst in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, provides a direct synthesis of α-tertiary amines, or their corresponding γ-lactams. We anticipate that this methodology will inspire new retrosynthetic disconnections for substituted amine derivatives in organic synthesis, and particularly for challenging α-tertiary primary amines.

Synthesis of γ-, δ-, and ε-lactams by asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters

Highly enantiomerically enriched γ- and δ-lactams have been prepared by a simple and very efficient procedure that involves the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters followed by desulfinylation of the nitrogen atom and spo

N,N-dibenzyl-n-[1-cyclohexyl-3-(trimethylsilyl)-2-propynyl]-amine from cyclohexanecarbaldehyde, trimethylsilylacetylene and dibenzylamine

-