927671-03-2

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(4-methoxyphenyl)amino]-
• CAS NO: 927671-03-2
• Molecular Formula: C20H17N3O5
• Molecular Weight: 379.372
• Mol File: 927671-03-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(4-methoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(4-methoxyphenyl)amino]-(927671-03-2)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(4-methoxyphenyl)amino]-(927671-03-2)

Safety Data

• Hazardous Substances Data: 927671-03-2(Hazardous Substances Data)

Upstream product

• 959150-64-2 (RS)-2-(2,6-dioxopiperidin-3-yl)-4-iodoisoindole-1,3-dione 
• 104-94-9 4-methoxy-aniline 
• 28418-88-4 3-iodophthalic anhydride 
• 31599-60-7 1-iodo-2,3-dimethylbenzene 
• 87-59-2 2,3-Dimethylaniline 
• 835616-60-9 2‐(2,6‐dioxopiperidin‐3‐yl)‐4‐fluoroisoindoline‐1,3‐dione 
• 927672-57-9 3-(4-methoxyphenylamino)phthalic acid 
• 24666-56-6 rac-α-aminoglutarimide hydrochloride 

Relevant articles and documents

Rapid synthesis of pomalidomide-conjugates for the development of protein degrader libraries

Current methods for the preparation of heterobifunctional pomalidomide-conjugates rely on methods that are often low yielding and produce intractable byproducts. Herein we describe our strategy for the reliable and succinct preparation of pomalidomide-linkers which is essential to the formation of these conjugates. We present the preparation of 18 pomalidomide-linkers in high yield compared to current literature methods. Our findings show that secondary amines consistently afford greater yields than their primary counterparts, a trend that we were able to exploit in the synthesis of several new pomalidomide homo-dimers in enhanced yields compared to similar literature syntheses. This trend was further utilised to develop the first one-pot synthesis of JQ1-pomalidomide conjugates in yields up to 62%, providing a method that is suited to rapid preparation of conjugate libraries as is frequently required for the development of new protein degraders.

Isoindole-imide compounds and compositions comprising and methods of using the same

This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.