927963-32-4

Basic information

• Product Name: 5-Hexynoic acid, 6-[2-amino-5-(trifluoromethyl)phenyl]-, methyl ester
• CAS NO: 927963-32-4
• Molecular Formula: C14H14F3NO2
• Molecular Weight: 285.266
• Mol File: 927963-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Hexynoic acid, 6-[2-amino-5-(trifluoromethyl)phenyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hexynoic acid, 6-[2-amino-5-(trifluoromethyl)phenyl]-, methyl ester(927963-32-4)
• EPA Substance Registry System: 5-Hexynoic acid, 6-[2-amino-5-(trifluoromethyl)phenyl]-, methyl ester(927963-32-4)

Safety Data

• Hazardous Substances Data: 927963-32-4(Hazardous Substances Data)

Upstream product

• 77758-51-1 methyl hex-5-ynoate 
• 16499-53-9 2-iodo-1-nitro-4-(trifluoromethyl)benzene 

Downstream Products

• 1203588-09-3 1-[[3-(1-Methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid 
• 1203588-10-6 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt 
• 1203588-11-7 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid piperazine salt 
• 1203588-12-8 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid tris(hydroxymethyl)aminomethane salt 
• 1203588-08-2 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester 
• 1203588-07-1 6-[2-(((3-(1-Methylethyl)phenyl)sulphonyl)amino]-5-(trifluoro-methyl)phenyl]-5-hexynoic acid, methyl ester 
• 927963-47-1 methyl 6-[2-(1,3-benzothiazol-6-ylsulfonylamino)-5-(trifluoromethyl)phenyl]hex-5-ynoate 

Relevant articles and documents

Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate

Here, we describe the identification and synthesis of novel indole sulfonamide derivatives that activate the three peroxisome proliferator activated receptor (PPAR) isoforms. Starting with a PPARα activator, compound 4, identified during a high throughput screening (HTS) of our proprietary screening library, a systematic optimization led to the discovery of lanifibranor (IVA337) 5, a moderately potent and well balanced pan PPAR agonist with an excellent safety profile. In vitro and in vivo, compound 5 demonstrated strong activity in models that are relevant to nonalcoholic steatohepatitis (NASH) pathophysiology suggesting therapeutic potential for NASH patients.