92817-10-2 Usage
Description
16ALPHA-FLUORO-17BETA-ESTRADIOL is a synthetic derivative of estradiol, a naturally occurring hormone and the primary female sex hormone. It is characterized by the presence of a fluorine atom at the 16-alpha position and a beta configuration at the 17-beta position. This modification results in altered pharmacological properties compared to the native hormone.
Used in Medical Imaging:
16ALPHA-FLUORO-17BETA-ESTRADIOL is used as a radiopharmaceutical agent for positron emission tomography (PET) imaging. It is particularly useful for visualizing the presence and distribution of specific estrogen receptors in the body, which can be crucial for diagnosing and monitoring various conditions and diseases related to estrogen receptor expression. The incorporation of a fluorine-18 radioisotope allows for effective detection and imaging of these receptors in a non-invasive manner.
Check Digit Verification of cas no
The CAS Registry Mumber 92817-10-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,8,1 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 92817-10:
(7*9)+(6*2)+(5*8)+(4*1)+(3*7)+(2*1)+(1*0)=142
142 % 10 = 2
So 92817-10-2 is a valid CAS Registry Number.
92817-10-2Relevant articles and documents
Alternative synthesis for the preparation of 16α-[ 18F]fluoroestradiol
Kil, Hee Seup,Cho, Han Yang,Lee, Sang Ju,Oh, Seung Jun,Chi, Dae Yoon
, p. 619 - 626 (2013)
We have developed a new precursor, 3,17β-O-bis(methoxymethyl)- 16β-O-p-nitrobenzenesulfonylestriol (14c) of 16α-[ 18F]fluoroestradiol ([18F]FES). Although we could not selectively protect the C17 alcohol in the presence of the C16 al
Cyclic sulfates: Useful substrates for selective nucleophilic substitution
Berridge,Franceschini,Rosenfeld,Tewson
, p. 1211 - 1217 (2007/10/02)
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Synthesis of 16-fluoroestrogens by unusually facile fluoride ion displacement reactions: Prospects for the preparation of fluorine-18 labeled estrogens
Kiesewetter,Katzenellenbogen,Kilbourn,Welch
, p. 4900 - 4905 (2007/10/02)
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