928324-88-3

Basic information

• Product Name: 5-(2-bromophenyl)-1H-pyrrole-3-carbaldehyde
• Synonyms: 5-(2-bromophenyl)-1H-pyrrole-3-carbaldehyde
• CAS NO: 928324-88-3
• Molecular Weight: 250.095
• Mol File: 928324-88-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2-bromophenyl)-1H-pyrrole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-bromophenyl)-1H-pyrrole-3-carbaldehyde(928324-88-3)
• EPA Substance Registry System: 5-(2-bromophenyl)-1H-pyrrole-3-carbaldehyde(928324-88-3)

Safety Data

• Hazardous Substances Data: 928324-88-3(Hazardous Substances Data)

Upstream product

• 7126-39-8 pyrrole-3-carboxaldehyde 
• 881676-32-0 5-bromo-1H-pyrrole-3-carboxaldehyde 
• 244205-40-1 (2-bromophenyl)boronic acid 

Downstream Products

• 928324-94-1 5-(2-bromophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3- ylsulfonyl)-1 H -pyrrol-3-yl]- n -methylmethanamine fumarate (tak-438) as a Potassium-Competitive Acid Blocker (P-CAB)

In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log"‰D and high ligand-lipophilicity efficiency (LLE) values. Among the compounds synthesized, the compound 13e exhibited potent H +,K+-ATPase inhibitory activity and potent gastric acid secretion inhibitory action in vivo. Its maximum efficacy was more potent and its duration of action was much longer than those of proton pump inhibitors (PPIs). Therefore, compound 13e (1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)- 1H-pyrrol-3-yl]-N-methylmethanamine fumarate, TAK-438) was selected as a drug candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases.