92852-66-9Relevant articles and documents
Design and Synthesis of 5-Oxoimidazolidine Derivatives in Search of Potent Antitubercular and Antifungal agents
Singirisetty, Triveni,Chilamakuru, Naresh Babu,Peraman, Ramalingam,Mallela, Vijaya Jyothi,Sana, Maheswari P.,Begum, Inthiyaz
, p. 441 - 451 (2021/02/02)
5-Oxoimidazolidines are significant outfits because of their impending biological activity and also because of their resourcefulness as synthons in organic revolutions. The designed library was docked against the crystal structure of Mycobacterium tuberculosis enoyl reductase (2B35) and crystal structure of flavohemoglobin (3OZU) to know the best fit molecule. The ADMET parameters revealed that the compounds have synthetic acceptability and leadlikeness. Accordingly, the selected 5-oxoimidazolidines (S1-8 and A1-8) were synthesized from carbohydrazides (1a-h) and characterized by spectral data. Further, these compounds were screened against M. tuberculosis H37RV by microplate Alamar Blue assay method. The compound S3 showed minimum inhibitory concentration at 6.25 μg/mL, while the antifungal screening demonstrated S1 as a promising lead with the corresponding zone of inhibitions of 22 mm and 18 mm against Aspergillus niger and Candida albicans.
