928840-99-7

Basic information

• Product Name: 2,4-DICHLORO-7-IODO-5H-PYRROLO[3,2-D]PYRIMIDINE
• Synonyms: 2,4-DICHLORO-7-IODO-5H-PYRROLO[3,2-D]PYRIMIDINE
• CAS NO: 928840-99-7
• Molecular Formula: C₆H₂Cl₂IN₃
• Molecular Weight: 313.91
• Mol File: 928840-99-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 2.337 g/cm³
• Refractive Index: 1.8
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DICHLORO-7-IODO-5H-PYRROLO[3,2-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-7-IODO-5H-PYRROLO[3,2-D]PYRIMIDINE(928840-99-7)
• EPA Substance Registry System: 2,4-DICHLORO-7-IODO-5H-PYRROLO[3,2-D]PYRIMIDINE(928840-99-7)

Safety Data

• Hazardous Substances Data: 928840-99-7(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine is a chemical compound with the molecular formula C6H2Cl2IN3. It is a pyrrolopyrimidine derivative with two chlorine atoms and one iodine atom attached to the pyrrolopyrimidine ring. 2,4-Dichloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine has potential applications in the field of medicinal chemistry and pharmaceuticals, as it exhibits interesting biological activities. Its unique structure and functional groups make it a promising candidate for the development of novel drugs targeting specific biological pathways. Further research on 2,4-Dichloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine may lead to the discovery of new therapeutic agents for various medical conditions.

InChI:InChI=1/C6H2Cl2IN3/c7-5-4-3(2(9)1-10-4)11-6(8)12-5/h1,10H

Upstream product

• 63200-54-4 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine 

Downstream Products

• 928841-01-4 5-(benzyloxymethyl)-2,4-dichloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine 
• 928841-21-8 5-(benzyloxymethyl)-2-chloro-7-[(trimethylsilyl)ethynyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine 
• 928841-16-1 5-(benzyloxymethyl)-2,4-dichloro-7-[(trimethylsilyl)ethynyl]-5H-pyrrolo[3,2-d]pyrimidine 
• 928841-23-0 1-[4-amino-5-(benzyloxymethyl)-2-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethane-1,2-diol 
• 928841-18-3 5-(benzyloxymethyl)-2-chloro-7-ethynyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine 
• 928841-12-7 5-(benzyloxymethyl)-2,4-dichloro-7-vinyl-5H-pyrrolo[3,2-d]pyrimidine 
• 928841-17-2 5-(benzyloxymethyl)-2,4-dichloro-7-ethynyl-5H-pyrrolo[3,2-d]pyrimidine 
• 928841-22-9 5-(benzyloxymethyl)-2-chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

C-Functionalization of 9-deazapurines by cross-coupling reactions

C-Functionalization of pyrrolo[3,2-d]pyrimidine scaffold in positions 2, 4, and 7 using cross-coupling reactions was performed. Thus, 2-(5-(benzyloxymethyl)-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)ethanol, a versatile synthetic precursor for 9-deazapurines and?4,6-diazaindoles, was prepared by vinylation of the corresponding iodide followed by hydroboration of the double bond. A synthesis of 9-(1,2-dihydroxyethyl)-9-deazaadenine, a 9-deaza-1′-nor congener to antiviral DHPA, was developed. In addition, an abnormal regioselectivity in methylalumination of the terminal triple bond in position 7 of the pyrrolo[3,2-d]pyrimidine scaffold leading to a transformation into (Z)-prop-1-enyl was observed.