929-59-9

Basic information

• Product Name: 1,8-Diamino-3,6-dioxaoctane
• Synonyms: 2,2’-[1,2-ethanediylbis(oxy)bis-ethanamin;1,8-DIAMINO-3,6-DIOXAOCTANE;1,2-BIS(2-AMINOETHOXY)ETHANE;2,2'-(ETHYLENEDIOXY)BIS(ETHYLAMINE);2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;ETHYLENE GLYCOL BIS(2-AMINOETHYL) ETHER;Amino-PEG2-Amine;1,8-Diamino-3,6-dioxaoctane for synthesis
• CAS NO: 929-59-9
• Molecular Formula: C₆H₁₆N₂O₂
• Molecular Weight: 148.2
• EINECS: 213-203-6
• Product Categories: Aliphatics;Amines
• Mol File: 929-59-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 105-109 °C6 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /Liquid
• Density: 1.015 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0369mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 9.04±0.10(Predicted)
• Water Solubility: Soluble in 0.4 parts water.
• Sensitive: Hygroscopic
• BRN: 1739187
• CAS DataBase Reference: 1,8-Diamino-3,6-dioxaoctane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Diamino-3,6-dioxaoctane(929-59-9)
• EPA Substance Registry System: 1,8-Diamino-3,6-dioxaoctane(929-59-9)

Safety Data

• Hazard Codes: C
• Statements: 22-34-42/43-37
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• F: 34
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 929-59-9(Hazardous Substances Data)

Usage

Description

Amino-PEG2-Amine is a crosslinker containing two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2,2'-(Ethylenedioxy)bis(ethylamine) is used to linker to form conjugates of manganese-doped zinc sulfide nanoparticles with folic acid.

Application

1,8-Diamino-3,6-dioxaoctane is a chelating agent that has been shown to have antibacterial efficacy against gram-positive bacteria. It has been demonstrated to bind to a variety of functionalities such as amines, low energy metals, and hydroxy groups. It has been studied in the synthesis of coordination complexes with a range of geometric structures. The synthesis methods for this compound include solid-phase synthesis and hydrolysis of ethylenediamine. This compound has also been used as an electron donor in fluorescence techniques and morphology studies.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2/p+2

Upstream product

• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 7664-41-7 ammonia 
• 80322-82-3 triethyleneglycol dimesylate 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 59086-77-0 1,6-dicyano-2,5-dioxahexane 
• 59559-06-7 1,8-diazido-3,6-dioxaoctane 
• 333-41-5 `Diazinon` 
• 31255-10-4 1,2-bis-(2-bromo-ethoxy)-ethane 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 31255-11-5 1,8-diphthalimido-3,6-dioxaoctane 

Downstream Products

• 118923-15-2 1,2-bis-[2-(2-hydroxy-3-methyl-benzylidenamino)-ethoxy]-ethane 
• 112744-28-2 N,N′-bis(salicylidene)-3,6-dioxa-1,8-diaminooctane 
• 67-42-5 ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid 
• 54945-27-6 6,9-dioxa-3,12,18-triazabicyclo[12.3.1]octadeca-1(18),14,16-triene-2,13-dione 
• 23978-55-4 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 
• 68394-43-4 (2S)-2r,3t-bis-benzyloxymethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane-6,17-dione 
• 56823-98-4 3-(5-tert-Butyl-4-hydroxy-2,3-dimethyl-phenyl)-N-[2-(2-{2-[3-(5-tert-butyl-4-hydroxy-2,3-dimethyl-phenyl)-propionylamino]-ethoxy}-ethoxy)-ethyl]-propionamide 
• 39678-15-4 10,13-bis-(toluene-4-sulfonyl)-1,4-dioxa-7,10,13,16-tetraaza-cyclooctadecane-8,15-dione 
• 97569-65-8 1,2-bis-<2-(2-carboxybenzamido)ethane> 
• 111039-13-5 1,14-Dioxa-4,6,9,11-tetraaza-cyclohexadecane-5,10-dithione 
• 120075-74-3 C₃₈H₄₀N₆O₆ 
• 92713-99-0 (2R,4aR,6S,6aR,22aS,22bR)-6-Methoxy-2-phenyl-dodecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene-9,20-dione 
• 74229-39-3 18-Benzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-2,6,17-trione 
• 89863-11-6 1,3,12,14-tetraaza-6,9,17,20,25,28-hexaoxabicyclo<12.8.8>triacontane-2,13-dithione 

Relevant articles and documents

A CHIRAL RESOLUTION METHOD MIMICKING MAGNETIC BENEFICIATION AND THE MAGNETIC NANO-INHIBITORS FOR SELECTIVE ENRICHMENT

A core-shell nanocomposite is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with its core being a hydrophobically modified magnetic nanomaterial and its shell being the amphiphilic polymer, wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell. The above composite can be used as additives in the crystallization of conglomerates and obtain optically pure crystals of both enantiomers in a single process. The key thereof is that the composite is used to enrich molecules with the same configuration while inhibit the crystallization of the other enantiomer in a supersaturated solution of conglomerates, such that a non-magnetic crystal and a magnetic crystal (which are enantiomers of each other) are generated in a unit operation. Optically pure crystals of both enantiomers with over 90 ee % can be obtained by one-time crystallization, and the total yield can be as high as 40%.

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

PEGylated atorvastatin derivative and preparation method thereof

The invention relates to a PEGylated atorvastatin derivative and a preparation method thereof. The method mainly comprises the following steps: 1) activating an end group of PEG; 2) enabling the activated PEG to react with atorvastatin to obtain an atorvastatin analogue. The structure of the atorvastatin analogue is: Atorvastatin-L-PEG-L-Atorvastatin, wherein Atorvastatin is atorvastatin; L is anester bond, an amido bond or other linking group; the PEG is residue of monodisperse polyethylene glycol; the structural formula of the atorvastatin analogue is shown in the description, where n is aninteger between 1 and 24. The preparation method has the advantages of short flow, easiness and convenience in reaction operation, few side reactions, low cost, high reaction selectivity, easiness inpurification and higher yield.