92953-41-8

Basic information

• Product Name: 3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide
• Synonyms: U-54494A;U-54494A HYDROCHLORIDE;CIS (+/-)-3,4-DICHLORO-N-METHYL-N-[2-(1-PYRROLIDINYL)CYCLOHEXYL]BENZAMIDE HCL;CIS-(+/-)-3,4-DICHLORO-N-METHYL-N-[2-(1-PYRROLIDINYL)CYCLOHEXYL]BENZAMIDE HYDROCHLORIDE;cis-(+/-)-3,4-Dichloro-N-Methyl-N-(2-[1-Pyrrolidinyl]Cyclo- Hexyl)Benzeneacetamide Hydrochloride
• CAS NO: 92953-41-8
• Molecular Formula: C₁₈H₂₄Cl₂N₂O
• Molecular Weight: 355.302
• Mol File: 92953-41-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 496.5°C at 760 mmHg
• Flash Point: 254.1°C
• Density: 1.25g/cm³
• Vapor Pressure: 5.38E-10mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide(92953-41-8)
• EPA Substance Registry System: 3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide(92953-41-8)

Safety Data

• Hazardous Substances Data: 92953-41-8(Hazardous Substances Data)

Usage

Description

3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide, also known as cis-(+/-)-3,4-Dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl)benzeneacetamide Hydrochloride and U-54494A Hydrochloride, is a benzamide compound that acts as an NMDA receptor/channel antagonist. It is characterized by its ability to inhibit NMDA receptor/channel activators, making it a potential candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide is used as an anti-convulsant agent for the treatment of seizure disorders. Its NMDA receptor antagonist properties help in reducing the frequency and severity of seizures by modulating the excitatory neurotransmission in the brain.
Used in Neurological Research:
In the field of neurological research, 3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide is used as a research tool to study the role of NMDA receptors in various neurological conditions, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Its ability to inhibit NMDA receptor/channel activators allows researchers to investigate the underlying mechanisms of these diseases and develop potential therapeutic strategies.
Used in Drug Development:
3,4-dichloro-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]benzamide is also used in drug development for the discovery of novel therapeutic agents targeting the NMDA receptor. Its unique structure and antagonistic properties make it a valuable starting point for the design and synthesis of new compounds with improved pharmacological profiles and therapeutic potential.