929617-39-0

Basic information

• Product Name: 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER
• Synonyms: 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER;tert-Butyl 6-amino-5-bromo-1H-indazole-1-carboxylate
• CAS NO: 929617-39-0
• Molecular Formula: C12H14BrN3O2
• Molecular Weight: 312.166
• Mol File: 929617-39-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER(929617-39-0)
• EPA Substance Registry System: 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER(929617-39-0)

Safety Data

• Hazardous Substances Data: 929617-39-0(Hazardous Substances Data)

Usage

General Description

The chemical "1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER" is a compound that belongs to the class of indazoles. It is a carboxylic acid derivative with a bromine substituent at the 5th position and an amino group at the 6th position. The compound is esterified with 1,1-dimethylethyl, also known as tert-butyl, resulting in the formation of a tert-butyl ester. 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER may have potential applications in pharmaceutical and chemical synthesis, as well as in the study of indazole derivatives and their biological activities. Further research and investigation may be required to fully understand the properties and potential uses of this chemical.

Upstream product

• 71785-49-4 5-bromo-6-nitro-1H-indazole 
• 71785-48-3 4-bromo-2-methyl-5-nitroaniline 
• 13194-70-2 4-bromo-2-methylaniline hydrochloride 
• 929617-38-9 5-bromo-6-nitro-1H-indazole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt

Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.