929910-68-9

Basic information

• Product Name: 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (4-chloro-3-trifluoromethyl-phenyl)-amide
• CAS NO: 929910-68-9
• Molecular Weight: 348.669
• Mol File: 929910-68-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (4-chloro-3-trifluoromethyl-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (4-chloro-3-trifluoromethyl-phenyl)-amide(929910-68-9)
• EPA Substance Registry System: 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (4-chloro-3-trifluoromethyl-phenyl)-amide(929910-68-9)

Safety Data

• Hazardous Substances Data: 929910-68-9(Hazardous Substances Data)

Upstream product

• 54828-05-6 1-methyl-4-nitro-1H-imidazole-5-carboxylic acid 
• 40648-96-2 1-methyl-4-nitro-1H-imidazole-5-carbonitrile 
• 61982-14-7 1-methyl-4-nitroimidazolyl-5-carboxylic acid chloroanhydride 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 

Relevant articles and documents

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.