93-21-0

Basic information

• Product Name: (2-NAPHTHYLTHIO)ACETIC ACID
• Synonyms: B-(NAPHTHYLMERCAPTO)ACETIC ACID;BETA-(NAPHTHYLMERCAPTO)ACETIC ACID;(2-NAPHTHYLTHIO)ACETIC ACID;S-(2-NAPHTHYL)THIOGLYCOLIC ACID;RARECHEM AL BO 1603;(2-naphthalenylthio)-aceticaci;2-(naphthalen-2-ylthio)acetic acid;(2-Naphthalenylthio)acetic acid
• CAS NO: 93-21-0
• Molecular Formula: C₁₂H₁₀O₂S
• Molecular Weight: 218.27
• EINECS: 202-229-3
• Mol File: 93-21-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 89-91 °C
• Boiling Point: 420.3oC at 760 mmHg
• Flash Point: 208oC
• Appearance: /
• Density: 1.31
• Vapor Pressure: 8.12E-08mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: (2-NAPHTHYLTHIO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-NAPHTHYLTHIO)ACETIC ACID(93-21-0)
• EPA Substance Registry System: (2-NAPHTHYLTHIO)ACETIC ACID(93-21-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 93-21-0(Hazardous Substances Data)

Usage

General Description

(2-Naphthylthio)acetic acid is a synthetic compound with the chemical formula C12H10O2S. It is a derivative of naphthalene and is used in various biological and biochemical research applications. The compound has been studied for its potential use in plant growth regulation, as it has been found to have growth-promoting effects on certain plants. (2-Naphthylthio)acetic acid has also been investigated for its role as a precursor in the synthesis of other biologically active compounds. In addition, it has been studied for its potential use in the treatment of certain medical conditions.

InChI:InChI=1/C12H10O2S/c13-12(14)8-15-11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8H2,(H,13,14)

Upstream product

• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 7433-79-6 2-methylthionaphthalene 
• 93-04-9 2-Methoxynaphthalene 
• 68-11-1 mercaptoacetic acid 
• 135-19-3 β-naphthol 
• 73632-20-9 sodium 1-naphthalenethiolate 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 
• 91-60-1 2-Naphthalenethiol 
• 107-59-5 tert-Butyl chloroacetate 
• 122831-48-5 ethyl 2-(naphthalen-2-ylthio)acetate 
• 80651-05-4 methyl 2-(naphthalen-2-ylthio)acetate 
• 61572-63-2 2-diazonaphthalene-1-sulphonic acid 

Downstream Products

• 82-60-0 naphtho[2,1-b]thiophen-1-ol 
• 60569-00-8 naphtho[2,1-b]thiophen-1-ol 
• 1110920-99-4 C₁₈H₁₅NO₂S 
• 5324-61-8 1,2-dihydro-naphtho[2,1-b]thiophene-3,3-dioxide 

Relevant articles and documents

Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia.

Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase

The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus E1 helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC50 value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.