93-26-5

Basic information

• Product Name: N-(2-Methoxyphenyl)acetamide
• Synonyms: N-(2-METHOXYPHENYL)ACETAMIDE;O-METHOXYACETANILIDE;O-ACETANISIDIDE;o-Acetaniside ;O-Methoxyacetanilide;O-Acetamidoanisole;2-Acetanisidine;o-Acetoanisidide;ACETYL ORTHO ANISIDINE;Acetylanisidine
• CAS NO: 93-26-5
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• EINECS: 202-233-5
• Product Categories: Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates
• Mol File: 93-26-5.mol
• Article Data: 129

Chemical Properties

• Melting Point: 70-74 °C(lit.)
• Boiling Point: 303-305 °C(lit.)
• Flash Point: 138.091 °C
• Appearance: /
• Density: 1.1603 (rough estimate)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.5839 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.50±0.70(Predicted)
• CAS DataBase Reference: N-(2-Methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methoxyphenyl)acetamide(93-26-5)
• EPA Substance Registry System: N-(2-Methoxyphenyl)acetamide(93-26-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: AE8280000
• Hazardous Substances Data: 93-26-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-7(11)10-8-5-3-4-6-9(8)12-2/h3-6H,1-2H3,(H,10,11)

Upstream product

• 4843-06-5 2-(2-methoxyphenyl)carbamoylacetic acid 
• 108-24-7 acetic anhydride 
• 90-04-0 2-methoxy-phenylamine 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 55860-22-5 2-chloro-N-(2-methoxyphenyl)acetamide 
• 7340-09-2 N-acetoxyacetamide 
• 100-66-3 methoxybenzene 
• 138-24-9 phenyltrimethylammonium chloride 
• 614-80-2 2-(acetylamino)phenol 
• 74-88-4 methyl iodide 
• 60-35-5 acetamide 
• 529-28-2 4-iodoanisol 
• 91-23-6 2-Nitroanisole 

Downstream Products

• 875240-32-7 2,2-bis-(3-acetylamino-4-methoxy-phenyl)-1,1,1-trichloro-ethane 
• 78943-68-7 N-acetyl-2-methoxy-2'-methyldiphenylamine 
• 91132-58-0 N-vinylacetyl-o-anisidine 
• 79874-39-8 3-(o-methoxyphenylamino)-1-butyne 
• 33721-54-9 N-(2-methoxy-5-nitrophenyl)acetamide 
• 93-27-6 5-nitro-2-acetylaminoanisole 
• 282107-73-7 N-Acetyl-N-(o-methoxyphenyl)glycine ethyl ester 
• 143360-01-4 N-(4-bromo-2-methoxyphenyl)acetamide 
• 5307-06-2 N-(4-hydroxy-2-methoxyphenyl)acetamide 
• 3251-56-7 2-methoxy-4-nitrophenol 
• 91170-71-7 3-acetylamino-4-methoxy-benzenesulfinic acid 
• 860677-90-3 bis-(3-amino-4-methoxy-phenyl)-disulfide 
• 860578-28-5 bis-(3-acetylamino-4-methoxy-phenyl)-disulfide 
• 124725-27-5 N-(3'-Acetylamino-4'-methoxyphenylsulfonyl)-N-methylaminomethylphosphonic acid 

Relevant articles and documents

A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination

A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.

Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides

A novel transformation of primary amides to secondary amides promoted by hypervalent iodine reagents was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents.

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.