93-47-0

Basic information

• Product Name: Verazide
• Synonyms: Verazide
• CAS NO: 93-47-0
• Molecular Formula: C₁₅H₁₅N₃O₃
• Molecular Weight: 285.302
• Mol File: 93-47-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 189-190°
• Appearance: /
• Density: 1.19g/cm³
• Refractive Index: 1.573
• CAS DataBase Reference: Verazide(CAS DataBase Reference)
• NIST Chemistry Reference: Verazide(93-47-0)
• EPA Substance Registry System: Verazide(93-47-0)

Safety Data

• Hazardous Substances Data: 93-47-0(Hazardous Substances Data)

Usage

Uses

Verazide is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).

InChI:InChI=1/C15H15N3O3/c1-20-13-4-3-11(9-14(13)21-2)10-17-18-15(19)12-5-7-16-8-6-12/h3-10H,1-2H3,(H,18,19)

Upstream product

• 54-85-3 isoniazid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 1260158-38-0 N-[5-(3',4'-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl]isonicotinamide 
• 1314013-42-7 2-(3,4-dimethoxyphenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole 

Relevant articles and documents

3,4-Dimethoxybenzaldehyde isonicotinoyl-hydrazone

Hydrogen bonds between the N2 and O1 atoms [2.879 (3) A] link molecules of the title Schiff base, C15H15N3O3, into a zigzag chain along the c axis. ? Alternative name: N-(3,4-dimethoxybenzylideneamino) isonicoti

Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies

Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis

Synthesis, characterization and pharmacological evaluation of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives as potent anticonvulsant agents

A series of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives were synthesized by coupling it with different substituted aldehydes, acetophenone, and benzophenones in presence of absolute ethanol along with catalytic amount of glacial aceti