930-87-0

Basic information

• Product Name: 1,2,5-TRIMETHYLPYRROLE
• Synonyms: 1,2,5-TRIMETHYLPYRROLE;1,2,5-Trimethyl-1H-pyrrole;1H-Pyrrole, 1,2,5-trimethyl-;Pyrrole, 1,2,5-trimethyl;1,2,5-Trimethylpyrrole,99%;1,2,5-Trimethylpyrrole 99%;NSC 81220
• CAS NO: 930-87-0
• Molecular Formula: C₇H₁₁N
• Molecular Weight: 109.17
• EINECS: 213-225-6
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrroles
• Mol File: 930-87-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 1.5°C (estimate)
• Boiling Point: 173 °C(lit.)
• Flash Point: 126 °F
• Appearance: clear yellow to brown liquid
• Density: 0.807 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.73mmHg at 25°C
• Refractive Index: n20/D 1.498(lit.)
• PKA: -0.26±0.70(Predicted)
• Water Solubility: Slightly soluble in water (2.2 g/L at 25°C).
• CAS DataBase Reference: 1,2,5-TRIMETHYLPYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-TRIMETHYLPYRROLE(930-87-0)
• EPA Substance Registry System: 1,2,5-TRIMETHYLPYRROLE(930-87-0)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 930-87-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H11N/c1-6-4-5-7(2)8(6)3/h4-5H,1-3H3

Upstream product

• 872273-79-5 1,5-dimethyl-4-pyrrolin-2-one 
• 75-16-1 methylmagnesium bromide 
• 123-39-7 N-Methylformamide 
• 110-13-4 2,5-hexanedione 
• 74-89-5 methylamine 
• 55341-97-4 1,2,5-trimethyl-3,4-diacetylpyrrole 
• 86397-83-3 diethyl 1,2,5-trimethyl-1H-pyrrole-3,4-dicarboxylate 
• 7664-93-9 sulfuric acid 
• 67-56-1 methanol 
• 2935-44-6 hexane-2,5-diol 
• 96326-30-6 1-Methyl-2,5-dimethylene-pyrrolidine 
• 1121-07-9 N-methylsuccinimide 
• 60-29-7 diethyl ether 
• 71-43-2 benzene 

Downstream Products

• 5449-87-6 1,2,5-trimethyl-1H-pyrrole-3-carbaldehyde 
• 31618-55-0 3,4-diformyl-1,2,5-trimethylpyrrole 
• 95679-86-0 Hydroxy-phenyl-(1,2,5-trimethyl-1H-pyrrol-3-yl)-acetic acid ethyl ester 
• 137123-49-0 2-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)malononitrile 
• 1310856-03-1 1,2,5-trimethyl-3-(4-nitrophenyl)pyrrole 
• 1030308-03-2 (R)-2-phenyl-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)ethanol 

Relevant articles and documents

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Reaction of methylamine with acetonylacetone and its application in polymer analysis

The reaction between methylamine and acetonylacetone is a very important one in pyrolysis polymer analysis. Polymers containing either primary amine functional groups or carbonyl functional groups separated by two methylene units can be derivatized by this reaction. The derivatized polymer undergoes a unique thermal degradation mechanism which favors qualitative and quantitative analysis by pyrolysis gas chromatography. In this study, the chromatographic and spectroscopice evidence about this reaction has been generated to verify this mechanism. The applications of this derivatization reaction in polymer analysis of (1) polyallylamine derivatized with acetonylacetone, (2) ethylene-carbon monoxide alternating copolymer derivatized with methylamine, and (3) ethylene-carbon monoxide, styrene- carbon monoxide alternating terpolymer derivatized with methylamine have been demonstrated.

A convenient one-pot synthesis of polysubstituted pyrroles from N-protected succinimides

The dienamine products formed by the reaction between polysubstituted succinimides and the Petasis reagent were subjected to isomerization under mild acidic conditions to give polysubstituted pyrroles in excellent yields (85-95%). The scope and limitations of this methodology are explored.