931-33-9

Basic information

• Product Name: 4-BROMOPYROLE-2-CARBOXALDEHYDE
• Synonyms: BUTTPARK 154\50-23;4-BROMOPYROLE-2-CARBOXALDEHYDE;4-BROMOPYRROLE-2-CARBOXALDEHYDE;4-Bromo-1H-pyrrole-2-carboxaldehyde;4-BroMo-2-pyrrolecarboxaldehyde;4-Bromo-2-formyl-1H-pyrrole;Pyrrole-2-carboxaldehyde, 4-bromo-
• CAS NO: 931-33-9
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 931-33-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 282.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.819±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.53±0.50(Predicted)
• CAS DataBase Reference: 4-BROMOPYROLE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOPYROLE-2-CARBOXALDEHYDE(931-33-9)
• EPA Substance Registry System: 4-BROMOPYROLE-2-CARBOXALDEHYDE(931-33-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 931-33-9(Hazardous Substances Data)

Usage

Uses

Twenty-one halo- and cyanopyrroles related to the trail pheromone of A. texana, Methyl 4-Methylpyrrole-2-carboxylate [34402-78-3], were prepared and tested by a faster and more sensitive bioassay than was previously available. Methyl 4-Chloropyrrole-2-carboxylate [1194-96-3] and Methyl 4-bromopyrrole-2-carboxylate appeared to be as active as the first one. Responsiveness of the ants in descending order to these compounds based on the constituent in the number two position, was: esters, methyl ketones, aldehydes.

Upstream product

• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 179928-10-0 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine 
• 177949-82-5 4-Phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde 
• 1056225-28-5 C₂₁H₁₈N₄O₃ 
• 1056225-13-8 C₂₁H₁₆N₄O₄ 
• 946847-39-8 C₁₉H₁₈N₂O₃S 
• 946847-38-7 C₂₀H₁₈N₂O₄S 
• 946847-37-6 C₁₉H₁₆N₂O₄S 
• 946847-36-5 C₁₉H₁₇NO₃S 
• 946847-35-4 C₁₈H₁₄FNO₃S 
• 946847-34-3 C₁₉H₁₇NO₄S 
• 946847-33-2 C₁₉H₁₅NO₅S 
• 946847-32-1 C₁₇H₁₄N₂O₃S 
• 276239-48-6 4-phenyl-1H-pyrrole-2-carbaldehyde 
• 850716-40-4 4-bromo-2-formyl-N-p-tosylpyrrole 

Relevant articles and documents

Substituted 1 (pyrrol 2 ylmethylene)pyrrolidinium salts a source of stable 2 azafulvenamines

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New azole antifungals with a fused triazinone scaffold

We identified a new series of azole antifungal agents bearing a pyrrolotriazinone scaffold. These compounds exhibited a broad in vitro antifungal activity against pathogenic Candida spp. (fluconazole-susceptible and fluconazole-resistant) and were 10- to 100-fold more active than voriconazole against two Candida albicans isolates with known mechanisms of azole resistance (overexpression of efflux pumps and/or specific point substitutions in the Erg11p/CYP51 enzyme). Our lead compound 12 also displayed promising in vitro antifungal activity against some filamentous fungi such as Aspergillus fumigatus and the zygomycetes Rhizopus oryzae and Mucor circinelloides and an in vivo efficiency against two murine models of lethal systemic infections caused by Candida albicans.

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors

Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cationic channel, plays critical roles in insulin release, cytokine production, body temperature regulation and cell death as a reactive oxygen species (ROS) and temperature sensor. However, few TRPM2 inhibitors have been reported, especially TRP-subtype selective inhibitors, which hampers the investigation and validation of TRPM2 as a drug target. To discover novel TRPM2 inhibitors, 3D similarity-based virtual screening method was employed, by which 2,3-dihydroquinazolin-4(1H)-one derivative H1 was identified as a TRPM2 inhibitor. A series of novel 2,3-dihydroquinazolin-4(1H)-one derivatives were subsequently synthesized and characterized. Their inhibitory activities against the TRPM2 channel were evaluated by calcium imaging and electrophysiology approaches. Some of the compounds exhibited significant inhibitory activity, especially D9 which showed an IC50 of 3.7 μM against TRPM2 and did not affect the TRPM8 channel. The summarized structure-activity relationship (SAR) provides valuable insights for further development of specific TRPM2 targeted inhibitors.