93159-88-7

Basic information

• Product Name: 11,12-DIMETHOXYDIHYDROKAWAIN
• Synonyms: 11,12-DIMETHOXYDIHYDROKAWAIN
• CAS NO: 93159-88-7
• Molecular Formula: C16H20O5
• Molecular Weight: 292.33
• Mol File: 93159-88-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 11,12-DIMETHOXYDIHYDROKAWAIN(CAS DataBase Reference)
• NIST Chemistry Reference: 11,12-DIMETHOXYDIHYDROKAWAIN(93159-88-7)
• EPA Substance Registry System: 11,12-DIMETHOXYDIHYDROKAWAIN(93159-88-7)

Safety Data

• Hazardous Substances Data: 93159-88-7(Hazardous Substances Data)

Usage

General Description

11,12-Dimethoxydihydrokawain is a natural compound and a kavalactone found in kava, a Pacific Island plant traditionally used for its sedative and anxiolytic effects. It is a member of the class of kavalactones, which are known for their psychoactive properties. 11,12-Dimethoxydihydrokawain has been studied for its potential as a natural alternative for managing anxiety and stress, and has been shown to modulate GABA receptors in the brain, leading to its calming effects. It also has potential as a treatment for conditions such as insomnia, muscle tension, and other stress-related disorders. The compound has been the subject of research for its pharmacological effects and potential therapeutic applications.

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Relevant articles and documents

In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice

Lung cancer is the leading cause of cancer-related deaths and chemoprevention should be developed. We recently identified dihydromethysticin (DHM) as a promising candidate to prevent NNK-induced lung tumorigenesis. To probe its mechanisms and facilitate its future translation, we investigated the structure-activity relationship of DHM on NNK-induced DNA damage in A/J mice. Twenty DHM analogs were designed and synthesized. Their activity in reducing NNK-induced DNA damage in the target lung tissues was evaluated. The unnatural enantiomer of DHM was identified to be more potent than the natural enantiomer. The methylenedioxy functional moiety did not tolerate modifications while the other functional groups (the lactone ring and the ethyl linker) accommodated various modifications. Importantly, analogs of high structural similarity to DHM with distinct efficacy in reducing NNK-induced DNA damage have been identified. They will serve as chemical probes to elucidate the mechanisms of DHM in blocking NNK-induced lung carcinogenesis.