93224-85-2

Basic information

• Product Name: 2-Bromo-6-chlorobenzoic acid
• Synonyms: BUTTPARK 51\01-28;2-BROMO-6-CHLOROBENZOIC ACID;AKOS MSC-0781;3-bromo-2-chloro-benzoic acid;6-bromo-2-chloroBenzoic acid;Benzoic acid, 2-broMo-6-chloro-
• CAS NO: 93224-85-2
• Molecular Formula: C₇H₄BrClO₂
• Molecular Weight: 235.46
• Product Categories: blocks;Bromides;Carboxes;Benzoic acid;API intermediates;Acids & Esters;Bromine Compounds;Chlorine Compounds;Acids and Esters
• Mol File: 93224-85-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 148-150°C
• Boiling Point: 315.883 °C at 760 mmHg
• Flash Point: 144.841 °C
• Appearance: /
• Density: 1.81 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.62±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-6-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-chlorobenzoic acid(93224-85-2)
• EPA Substance Registry System: 2-Bromo-6-chlorobenzoic acid(93224-85-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: 2811
• WGK Germany: 2
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 93224-85-2(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

InChI:InChI=1/C7H4BrClO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11)

Upstream product

• 62356-27-8 2-bromo-6-chlorotoluene 
• 118-91-2 ortho-chlorobenzoic acid 
• 124-38-9 carbon dioxide 
• 104514-49-0 3-chloro-1,2-dibromobenzene 
• 108-37-2 1-bromo-3-chlorobenzene 
• 768-66-1 2,2,6,6-tetramethyl-piperidine 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 606-20-2 2,6-dinitrotoluene 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 116529-65-8 2-bromo-6-chlorobenzoyl chloride 
• 685892-23-3 methyl 2-acetyl-6-chlorobenzoate 
• 1075714-89-4 2-chloro-6-(1-methoxycarbonyl-2-oxo-propyl)-benzoic acid 
• 59772-49-5 2-bromo-6-chloroaniline 
• 1253186-31-0 2-bromo-6-chloro-N-{1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-3-yl}benzamide 
• 1338224-12-6 methyl 4-(8-chloro-4-methyl-1-oxophthalazin-2(1H)-yl)benzoate 
• 1338224-13-7 4-(8-chloro-4-methyl-1-oxophthalazin-2(1H)-yl)benzoic acid 
• 20771-95-3 methyl 2-acetyl-6-chlorobenzoate 
• 1070870-37-9 2-bromo-6-chloro-N-phenylbenzamide 
• 1562995-49-6 methyl 2-chloro-6-vinylbenzoate 
• 1562995-51-0 2-chloro-6-(prop-1-en-2-yl)benzoic acid 
• 1562995-59-8 2-chloro-6-cyclohexylbenzoic acid 
• 1562995-60-1 2-chloro-6-cyclohexylbenzoyl chloride 
• 403479-37-8 methyl cyclohexylbenzoate 

Relevant articles and documents

Synthesis of pyrrolnitrin and related halogenated phenylpyrroles

A general approach to halogenated arylpyrroles, including the antifungal natural product pyrrolnitrin, is described using newly synthesized halogenated pyrroles and 2,6-disubstituted nitrobenzenes or 2,6-disubstituted anilines.

RENIN INHIBITORS

Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.

Halogen-metal exchange of 3-substituted 1,2-dibromoarenes: The use of long-range JCH coupling constants to determine regiochemistry

Regioselective halogen/metal exchange reactions were carried out on a series of 3-substituted-1,2-dibromoarenes. Product mixtures were quenched with CO2 to form the corresponding benzoic acid analogs to facilitate HPLC and NMR analysis. Substitution at the 3-position could readily be assigned on the basis of 2D HMBC long-range correlations, while assignment at the 2-position was not as straightforward. The use of three-bond JCH coupling constant measurements, extracted from 1-D 1H coupled 13C experiments, were necessary to render unequivocal regio assignments. Copyright