932720-97-3Relevant articles and documents
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit
Chan, A. W. Edith,Greenwood, Simon O. R.,Hansen, D. Flemming,Marson, Charles M.
, (2020/01/22)
A series of potent inhibitors of histone deacetylase-8 (HDAC8) is described that contains an α-amino amide zinc-binding unit and a substituted isoindolinyl capping group. The presence of a 2,4-dichlorophenyl unit located in the acetate-release cavity was