932986-18-0 Usage
Description
N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide is a small molecule compound that has been demonstrated to possess significant biological activities. It is known for its ability to modulate the endoplasmic reticulum (ER) protein-folding process and enhance the ER chaperone capacity, which is crucial for maintaining cellular homeostasis and protecting cells against ER stress. N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide also exhibits antidiabetic properties, making it a promising candidate for the development of therapeutic agents targeting various diseases and conditions.
Uses
Used in Pharmaceutical Industry:
N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide is used as a therapeutic agent for the treatment of neurodegenerative diseases, cancers, and metabolic syndrome. Its ability to improve ER protein-folding ability and activate ER chaperone capacity helps alleviate chronic ER stress, which is strongly associated with these conditions.
Used in Diabetes Management:
In the field of diabetes management, N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide is used as an antidiabetic agent. It has been shown to improve insulin sensitivity and pancreatic β cell function, thereby enhancing glucose homeostasis and offering protection against ER stress in pancreatic β cells.
Used in Drug Development:
N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide is utilized in drug development as a lead compound for the design and synthesis of novel therapeutic agents targeting the endoplasmic reticulum stress response. Its multifaceted activities make it a valuable tool in the development of treatments for a wide range of diseases and conditions.
Used in Research Applications:
In research settings, N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide serves as a valuable research tool for studying the mechanisms underlying the unfolded protein response (UPR) and ER stress. Its ability to modulate the expression of chaperone proteins and influence the phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) makes it instrumental in advancing our understanding of cellular stress responses and their implications in various pathological processes.
References
1) Fu?(2015), Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity; Sci. Transl. Med., 7?292ra98
Check Digit Verification of cas no
The CAS Registry Mumber 932986-18-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,2,9,8 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 932986-18:
(8*9)+(7*3)+(6*2)+(5*9)+(4*8)+(3*6)+(2*1)+(1*8)=210
210 % 10 = 0
So 932986-18-0 is a valid CAS Registry Number.
932986-18-0Relevant articles and documents
PROCESS FOR PREPARING A POTENT THIAZOLE COMPOUND, PHARMACEUTICAL FORMULATION AND USES THEREOF
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, (2019/11/12)
The present invention relates to a process for preparing N-[2-[2-(4-chlorophenyl)-4- thiazolyl] ethyl]-butanamide. The present invention further relates to a pharmaceutical formulation and the use of said pharmaceutical formulation consisting of N-[2-[2-(
