93366-88-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)
• Synonyms: 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI);2-Amino-7H-pyrrolo[2,3-d]pyrimidine;1H-Pyrrolo[2,3-d]pyrimidin-2-amine;2-AMino-7H-pyrrolo[2,3-d]...;7H-Pyrrolo[2,3-d]pyriMidin- 2-aMine;7H-Pyrrolo[2,3-d]pyrimidin-2-amin;2-Amino-7H-pyrrolopyrimidin
• CAS NO: 93366-88-2
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.13864
• Product Categories: PYRIMIDINE
• Mol File: 93366-88-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 359.786 °C at 760 mmHg
• Flash Point: 171.393 °C
• Appearance: /
• Density: 1.619 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.824
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.05±0.20(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)(93366-88-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI)(93366-88-2)

Safety Data

• Hazardous Substances Data: 93366-88-2(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI) is a chemical compound with a molecular formula C7H7N5. It is a heterocyclic aromatic amine, which means that it contains a cyclic structure with at least one nitrogen atom. 1H-Pyrrolo[2,3-d]pyrimidin-2-amine (9CI) has potential applications in the pharmaceutical industry, particularly in the development of drugs targeting specific biological pathways. Its structure suggests that it may have biological activity by interacting with enzymes or receptors in the body. However, further research and testing would be necessary to fully understand its potential uses and properties.

InChI:InChI=1/C6H6N4/c7-6-9-3-4-1-2-8-5(4)10-6/h1-3H,(H3,7,8,9,10)

Upstream product

• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 335654-06-3 2-chloro-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 93366-94-0 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin 
• 93366-95-1 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin 
• 93366-97-3 2-Amino-7-(2-desoxy-α-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin 
• 1208228-64-1 C₁₉H₂₄N₆OSi 

Relevant articles and documents

Design and evaluation of a potential mutagen for Hepatitis C virus

Pyrrolopyrimidine nucleoside 1 was designed and synthesized as a potential mutagen for HCV. An in vitro HCV NS5B enzymatic assay indicated that pyrrolopyrimidine triphosphate acts as a CTP analog rather than a UTP analog. The SATE-prodrug of pyrrolopyrimidine monophosphate showed a weak inhibitory activity in an HCV replicon system (EC50 = 60 μM) and did not exhibit cytotoxicity (CC50 > 100 μM). Investigation of phosphorylation events using nucleoside kinases and LC-MS analysis revealed that the second phosphorylation step, from monophosphate ester to diphosphate ester, is unfavorable.

COMPOUNDS FOR THE TREATMENT OF HIV

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

CYTIDINE ANALOGS AND METHODS OF USE

Cytidine analogs, their prodrugs and/or metabolites are employed as pharmaceutically active compounds for treatment of diseases responsive to such compounds. Particularly preferred diseases include viral diseases (e.g., HCV infection) and neoplasms.