93470-26-9

Basic information

• Product Name: (R)-1-CYCLOHEXYLETHYL ISOCYANATE
• Synonyms: (R)-1-CYCLOHEXYLETHYL ISOCYANATE
• CAS NO: 93470-26-9
• Molecular Formula: C₉H₁₅NO
• Molecular Weight: 153.22
• EINECS: -0
• Mol File: 93470-26-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 210-215°C
• Flash Point: 210-215°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.161mmHg at 25°C
• Refractive Index: 1.4650
• Sensitive: Moisture Sensitive
• BRN: 9255848
• CAS DataBase Reference: (R)-1-CYCLOHEXYLETHYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-CYCLOHEXYLETHYL ISOCYANATE(93470-26-9)
• EPA Substance Registry System: (R)-1-CYCLOHEXYLETHYL ISOCYANATE(93470-26-9)

Safety Data

• Statements: 25-36/37/38
• Safety Statements: 20-26-36/37-45-60
• RIDADR: 2488
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 93470-26-9(Hazardous Substances Data)

Usage

General Description

(R)-1-Cyclohexylethyl isocyanate is a chemical compound with the molecular formula C9H15NO. It is a highly reactive compound that is commonly used as a building block in the synthesis of various polymers, including polyurethanes and polyureas. (R)-1-CYCLOHEXYLETHYL ISOCYANATE is characterized by its strong, pungent odor and its ability to polymerize rapidly upon exposure to moisture. It is considered to be a hazardous chemical and proper safety precautions should be taken when handling and storing it. Additionally, exposure to (R)-1-Cyclohexylethyl isocyanate should be minimized to prevent any potential health risks, as it is known to be a respiratory and skin irritant.

InChI:InChI=1/C9H15NO/c1-8(10-7-11)9-5-3-2-4-6-9/h8-9H,2-6H2,1H3/t8-/m1/s1

Upstream product

• 5913-13-3 [(1R)-1-cyclohexylethyl]amine 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

The present invention provides compounds that inhibit Factor XIa or kallikrein and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of making these compounds or pharmaceutically acceptable sal

Influence of bulky substituents on histamine H3 receptor agonist/antagonist properties

Novel derivatives of 3-(1H-imidazol-4-yl)propanol were designed on the basis of lead compounds belonging to the carbamate or ether series possessing (partial) agonist properties on screening assays of the histamine H3 receptor. One pair of enantiomers in the series of α-methyl-branched chiral carbamates was stereoselectively prepared in high optical yields. Enantiomeric purity was checked by Mosher amide derivatives of precursors and capillary electrophoresis of the final compounds with trimethyl-β-cyclodextrin as chiral selector, and was determined to be ≥95%. The novel compounds were investigated in various histamine H3 receptor assays in vitro and in vivo. Some compounds displayed partial agonist activity on synaptosomes of rat brain cortex, whereas others exhibited antagonist properties only. Selected compounds were investigated in [125I]iodoproxyfan binding studies on the human histamine H3 receptor and showed high affinity in the nanomolar concentration range. Under in vivo conditions after oral administration to mice, some of the compounds exhibited partial or full agonist activity in the brain at low dosages. The (S)-enantiomer of one pair of chiral carbamates (9) proved to be the eutomer; thus, the (S)-enantiomer was selected for further pharmacological studies. In a peripheral in vivo test model in rats, measuring the level of inhibition of capsaicin-induced plasma extravasation, (S)-9 again proved its high oral agonist potency with full intrinsic activity (ED50 values of 0.07-0.1 mg/kg depending on tissue).