934842-69-0Relevant articles and documents
Preparation method of Salmeterol Xinafoate
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, (2017/08/27)
The invention discloses a preparation method of Salmeterol Xinafoate. The method comprises the following steps: condensation reaction of a compound 2 and a compound 3 under alkaline conditions to obtain an intermediate 4; acidic hydrolysis to obtain an intermediate 5, and reduction reaction of the intermediate 5 to obtain an intermediate 6; debenzylation of the intermediate 6 by use of palladium carbon (Pd / C) to obtain a salmeterol basic group; and salification from the salmeterol basic group and 1-hydroxy-2-naphthoic acid to obtain the Salmeterol Xinafoate. The preparation method has the advantages of mild reaction condition, simple post-treatment, low cost, high yield, high product purity and easy industrialization.
PROCESS FOR THE PREPARATION OF SALMETEROL XINAFOATE
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, (2017/11/03)
The present invention relates to an improved process for the preparation of Salmeterol Xinafoate of Formula (I).
A new synthetic approach to salmeterol
Rong, Yajing,Ruoho, Arnold E.
, p. 2155 - 2162 (2007/10/03)
In the present work a short and convenient route for the synthesis of salmeterol from salicylaldehyde has been developed.