935534-40-0

Basic information

• Product Name: 2-Bromo-5-fluoro-4-nitropyridine 1-oxide
• Synonyms: 2-Bromo-5-fluoro-4-nitropyridine 1-oxide;2-bromo-5-fluoro-4-nitro-1-oxidopyridin-1-ium;2-Bromo-5-fluoro-4-nitropyridine
• CAS NO: 935534-40-0
• Molecular Formula: C5H2BrFN2O3
• Molecular Weight: 236.99
• Mol File: 935534-40-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 440.3±40.0 °C(Predicted)
• Appearance: /
• Density: 2.08±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.24±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5-fluoro-4-nitropyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluoro-4-nitropyridine 1-oxide(935534-40-0)
• EPA Substance Registry System: 2-Bromo-5-fluoro-4-nitropyridine 1-oxide(935534-40-0)

Safety Data

• Hazardous Substances Data: 935534-40-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-fluoro-4-nitropyridine 1-oxide is a chemical compound with the molecular formula C5H2BrFNO3. It is a derivative of pyridine and is known for its use in pharmaceutical and agrochemical research. 2-Bromo-5-fluoro-4-nitropyridine 1-oxide is often used as a building block in the synthesis of various organic compounds due to its unique properties and reactivity. It is also used in the production of active pharmaceutical ingredients and in the development of new chemical entities. Additionally, 2-Bromo-5-fluoro-4-nitropyridine 1-oxide has potential applications in the field of medicinal chemistry and drug discovery. Overall, this compound is a valuable tool for researchers in the development of new drugs and agrochemicals.

Upstream product

• 935534-39-7 2-bromo-5-fluoro-1-oxido-pyridin-1-ium 
• 41404-58-4 2-bromo-5-fluoropyridine 

Relevant articles and documents

STING PYRAZOLE AGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the modulation of STING, and the treatment of STING-mediated disorders.

Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships

We previously reported a novel series of 1H-pyrazolo[3,4-c]pyridine derivatives and the identification of compound 4b as a highly potent GPR119 agonist. However, the advancement of preclinical evaluations of compound 4b is expected to be difficult because of the compound's significantly poor aqueous solubility (0.71?μM at pH6.8). In this article, we describe the further optimization of compound 4b focusing on the improvement of its aqueous solubility. Optimization of the central spacer, left-hand aryl group and right-hand piperidine N-capping group led to the identification of a potent GPR119 agonist, 3H-[1,2,3]triazolo[4,5-c]pyridine derivative 32o, with improved solubility (15.9?μM at pH6.8).

PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS

Pesticidally active bi-or tricyclic heterocycles with sulphur-containing substituents, stereoisomers and tautomeric forms thereof that can be used as insecticides and can be prepared in a manner known per se.